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Impact of Abdominal Aortic Calcification on Central Haemodynamics and Decline of Glomerular Filtration Rate in Patients with Chronic Kidney Disease Stages 3 and 4
Univ Gothenburg, Inst Med, Dept Mol & Clin Med Nephrol, Sahlgrenska Acad, Gothenburg, Sweden.
Univ Gothenburg, Inst Med, Dept Mol & Clin Med Nephrol, Sahlgrenska Acad, Gothenburg, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
Univ Gothenburg, Inst Clin Sci, Dept Radiol, Sahlgrenska Acad, Gothenburg, Sweden.
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2019 (English)In: Kidney and Blood Pressure Research, ISSN 1420-4096, E-ISSN 1423-0143, Vol. 44, no 5, p. 950-960Article in journal (Refereed) Published
Abstract [en]

Background/Aim: Calcifications of large arteries are frequent in chronic kidney disease (CKD) and may contribute to the high cardiovascular risk in this population. The aim of this study was to examine whether abdominal aortic calcification volume (AACV) was a predictor of the rate of decline in glomerular filtration rate (GFR) in a cohort of patients with CKD stages 3 and 4. Methods: Eighty-four patients with CKD stages 3 and 4 were enrolled in this prospective observational study. At study entry, and annually, GFR was measured by plasma Cr-51-EDTA clearance. At baseline, haemodynamics was assessed and AACV was determined by computer tomography. Results: The mean follow-up time was 3.4 years and mean decline in GFR was -2.69 mL/min/1.73 m(2) per year. At baseline, abdominal aortic calcification (AAC) was detected in 66 patients (79%). A binary logistic regression analysis revealed that age was the only statistically significant independent predictor of AAC. In patients with AAC, male gender (B = 0.413, p = 0.030), aortic diastolic blood pressure (B = -0.025, p = 0.001) and ankle-brachial index (B = -1.666, p = 0.002) were independently associated with AACV using a multiple linear regression analysis. Neither the presence nor the extent of AAC was significantly associated with the rate of change in GFR during follow-up. Conclusion: In this cohort of patients with CKD stages 3 and 4, only age was an independent predictor of the presence of AAC. AACV was not associated with the rate of decline in GFR. (c) 2019 The Author(s)

Place, publisher, year, edition, pages
KARGER , 2019. Vol. 44, no 5, p. 950-960
Keywords [en]
Ankle-brachial index, Pulse pressure, Pulse wave velocity, Sclerostin, Vascular calcification
National Category
Urology and Nephrology Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-397312DOI: 10.1159/000501687ISI: 000493120100007PubMedID: 31437840OAI: oai:DiVA.org:uu-397312DiVA, id: diva2:1371239
Funder
Swedish Heart Lung FoundationAvailable from: 2019-11-19 Created: 2019-11-19 Last updated: 2019-11-19Bibliographically approved

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