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UNALTERED LOW NERVE GROWTH FACTOR AND HIGH BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN PLASMA FROM PATIENTS WITH FIBROMYALGIA AFTER A 15-WEEK PROGRESSIVE RESISTANCE EXERCISE
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.ORCID iD: 0000-0003-4420-418X
Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Karolinska Univ Hosp, Sweden.
Univ Gothenburg, Sweden.
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2019 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 51, no 10, p. 779-787Article in journal (Refereed) Published
Abstract [en]

Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotro-phins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hyperalgesia. Few studies have examined circulating nerve growth factor and brain-derived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these peptides. Objectives: To compare plasma levels of nerve growth factor and brain-derived neurotrophic factor in fibromyalgia and in healthy controls, to investigate correlations between levels of nerve growth factor, brain-derived neurotrophic factor, and cytokines and clinical variables, and to investigate the effect of exercise on these levels. Subjects and methods: A total of 75 women with fibromyalgia participated in blood tests at baseline and after the 15-week intervention, and 25 healthy controls participated at baseline. Patients were randomized to a 15-week progressive resistance exercise intervention or a relaxation intervention. Results: Brain-derived neurotrophic factor level was significantly higher (p amp;lt;0.001) and nerve growth factor level was significantly lower (p amp;lt;0.001) in fibromyalgia than in healthy controls. Neither resistance exercise nor relaxation interventions affected the levels of brain-derived neurotrophic factor or nerve growth factor. No significant correlations were found between brain-derived neurotrophic factor or nerve growth factor plasma levels in fibromyalgia and cytokine levels or clinical variables. Conclusion: Changes in circulating nerve growth factor and brain-derived neurotrophic factor levels may affect nociception/pain in fibromyalgia. Clinical improvements were achieved following the exercise intervention, but the levels of brain-derived neurotrophic factor and nerve growth factor were not normalized.

Place, publisher, year, edition, pages
FOUNDATION REHABILITATION INFORMATION , 2019. Vol. 51, no 10, p. 779-787
Keywords [en]
brain-derived neurotrophic factor; biomarker; chronic pain; fibromyalgia; nerve growth factor; plasma
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-161838DOI: 10.2340/16501977-2593ISI: 000492730500008PubMedID: 31544950OAI: oai:DiVA.org:liu-161838DiVA, id: diva2:1370899
Note

Funding Agencies|Swedish Rheumatism Association; Health and Medical Care Executive Board of Vastra Gotaland Region; Stockholm County Council (ALF)Stockholm County Council; ALF grants at Region Ostergotland; Linkoping University Hospital Research Fund; Swedish Research CouncilSwedish Research Council [K2013-52X-22199-01-3, K2015-99x-21874-05-4, 521-2010-2893]; AFA Insurance [140341]; ALF-LUA at Sahlgrenska University Hospital

Available from: 2019-11-18 Created: 2019-11-18 Last updated: 2020-01-09

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Jablochkova, AnnaBäckryd, EmmanuelGerdle, BjörnGhafouri, Bijar
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