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Cellular Interactions in the Intestinal Stem Cell Niche
2019 (English)In: Archivum Immunologiae et Therapiae Experimentalis, ISSN 0004-069X, E-ISSN 1661-4917, Vol. 67, no 1, p. 19-26Article, review/survey (Refereed) Published
Abstract [en]

Epithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial regulatory signals for the maintenance and regeneration of epithelial cells. Here, we discuss the role of intestinal myofibroblasts, α-smooth muscle actin-positive stromal (mesenchymal) cells, as an important regulatory part of the intestinal stem cell niche. Better understanding of the cross-talk between myofibroblasts and the epithelium in the intestine has implications for advances in regenerative medicine, and improved therapeutic strategies for inflammatory bowel disease, intestinal fibrosis and colorectal cancer.

Place, publisher, year, edition, pages
Springer, 2019. Vol. 67, no 1, p. 19-26
Keywords [en]
Mesenchymal–epithelial cross-talk, Inflammatory bowel disease, Myofibroblasts, Intestinal stem cells, Stem cell niche
National Category
Cell Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-165232DOI: 10.1007/s00005-018-0524-8ISI: 000458285000002PubMedID: 30242440OAI: oai:DiVA.org:umu-165232DiVA, id: diva2:1370571
Available from: 2019-11-15 Created: 2019-11-15 Last updated: 2019-11-18Bibliographically approved

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Pastula, Agnieszka
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