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CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
KTH Royal Inst Technol, Dept Prot Sci, Div Affin Prote, SciLifeLab, Tomtebodvagen 23A, Stockholm, Sweden.
KTH Royal Inst Technol, Dept Prot Sci, Div Affin Prote, SciLifeLab, Tomtebodvagen 23A, Stockholm, Sweden.ORCID iD: 0000-0001-6560-6124
KTH Royal Inst Technol, Dept Prot Sci, Div Affin Prote, SciLifeLab, Tomtebodvagen 23A, Stockholm, Sweden.
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2019 (English)In: Journal of Pain Research, ISSN 1178-7090, E-ISSN 1178-7090, Vol. 12, p. 2875-2889Article in journal (Refereed) Published
Abstract [en]

Objective: Neuropathic pain and fibromyalgia are two common and poorly understood chronic pain conditions that lack satisfactory treatments, cause substantial suffering and societal costs. Today, there are no biological markers on which to base chronic pain diagnoses, treatment choices or to understand the pathophysiology of pain for the individual patient. This study aimed to investigate cerebrospinal fluid (CSF) protein profiles potentially associated with fibromyalgia and neuropathic pain. Methods: CSF samples were collected from 25 patients with neuropathic pain (two independent sets, n=14 patients for discovery, and n=11 for verification), 40 patients with fibromyalgia and 134 controls without neurological disease from two different populations. CSF protein profiling of 55 proteins was performed using antibody suspension bead array technology. Results: We found increased levels of apolipoprotein C1 (APOC1) in CSF of neuropathic pain patients compared to controls and there was a trend for increased levels also in fibromyalgia patients. In addition, levels of ectonucleotide pyrophosphatase family member 2 (ENPP2, also referred to as autotaxin) were increased in the CSF of fibromyalgia patients compared to all other groups including patients with neuropathic pain. Conclusion: The increased levels of APOC1 and ENPP2 found in neuropathic pain and fibromyalgia patients may shed light on the underlying mechanisms of these conditions. Further investigation is required to elucidate their role in maintaining pain and other main symptoms of these disorders.

Place, publisher, year, edition, pages
Dove Medical Press LTD , 2019. Vol. 12, p. 2875-2889
Keywords [en]
cerebrospinal fluid, neuropathic pain, fibromyalgia, antibody suspension bead arrays, APOC1, ENPP2
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-396441DOI: 10.2147/JPR.S215348ISI: 000490123900002PubMedID: 31686904OAI: oai:DiVA.org:uu-396441DiVA, id: diva2:1370023
Funder
VinnovaSwedish Research CouncilEU, FP7, Seventh Framework Programme, 607616Available from: 2019-11-13 Created: 2019-11-13 Last updated: 2019-11-22Bibliographically approved

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Lind, Anne-LiMikus, MariaGhafouri, BijarGordh, Torsten
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