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When age really matters: ferritin reference intervals during infancy revisited
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2019 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686Article in journal (Refereed) Epub ahead of print
Abstract [en]

Infants are at risk for iron deficiency. Despite research advances, assessing iron stores during infancy remains a challenge to the clinician. Ferritin is the first-choice laboratory marker for measuring iron stores but it is today still unclear how to evaluate reference intervals among infants. We have studied Swedish infants (n = 456), born at term after normal pregnancies. Ferritin was measured at birth (umbilical cord sample), 48-72 h, 4 months and 12 months. Lower and upper reference interval limits were constructed as the 2.5th and 97.5th percentiles. By a large study population, we were able to use more stringent measures to avoid interference from the acute phase response than previous reports on ferritin reference intervals. When we used mathematical transformation we furthermore avoided potential information loss in precision and confirmed earlier reports of sex differences. At the lower reference interval limits there were small differences between sexes. For the higher limits, the differences were more pronounced in the older infant. At 0-3 d of age we observed a difference between the sexes of only 5% at the upper limits. The differences peaked at 12 months, where the boys' upper 97.5th percentile was 56% compared to girls.

Place, publisher, year, edition, pages
Taylor & Francis, 2019.
Keywords [en]
Ferritin, pediatrics, reference intervals, infant, iron deficiency
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-165112DOI: 10.1080/00365513.2019.1681028ISI: 000491981800001PubMedID: 31642699OAI: oai:DiVA.org:umu-165112DiVA, id: diva2:1369970
Available from: 2019-11-13 Created: 2019-11-13 Last updated: 2019-11-13

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