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Bilateral vessel-outlining carotid artery calcifications in panoramic radiographs: an independent risk marker for vascular events
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0003-1320-4400
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0002-9599-5615
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
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2019 (English)In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 19, no 1, article id 225Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: In odontology, panoramic radiographs (PRs) are regularly performed. PRs depict the teeth and jaws as well as carotid artery calcifications (CACs). Patients with CACs on PRs have an increased risk of vascular events compared to healthy controls without CACs, but this association is often caused by more vascular events and risk factors at baseline. However, the risk of vascular events has only been analyzed based on the presence of CACs, and not their shape. Thus, this study determined if the shape of CACs in PRs affects the risk of future vascular events.

METHODS: The study cohort included 117 consecutive patients with CACs in PRs and 121 age-matched controls without CACs. CAC shape in PRs was dichotomized into bilateral vessel-outlining CACs and other CAC shapes. Participants were followed prospectively for an endpoint of vascular events including myocardial infarction, stroke, and vascular death.

RESULTS: Patients with bilateral vessel-outlining CACs had more previous vascular events than those with other CAC shapes and the healthy controls (p < 0.001, χ2). The mean follow-up duration was 9.5 years. The endpoint was reached in 83 people. Patients with bilateral vessel-outlining CACs had a higher annual risk of vascular events (7.0%) than those with other CAC shapes (4.4%) and the controls (2.6%) (p < 0.001). In multivariate analysis, bilateral vessel-outlining CACs (hazard ratio: 2.2, 95% confidence interval: 1.1-4.5) were independent risk markers for the endpoint.

CONCLUSIONS: Findings of bilateral vessel-outlining CACs in PRs are independent risk markers for future vascular events.

Place, publisher, year, edition, pages
BioMed Central, 2019. Vol. 19, no 1, article id 225
Keywords [en]
Cardiovascular disease, Carotid atherosclerosis, Panoramic radiography
National Category
Medical and Health Sciences Clinical Medicine
Research subject
Medicine; Odontology
Identifiers
URN: urn:nbn:se:umu:diva-164795DOI: 10.1186/s12872-019-1211-3ISI: 000490832600004PubMedID: 31619183OAI: oai:DiVA.org:umu-164795DiVA, id: diva2:1367205
Funder
Swedish Heart Lung FoundationVästerbotten County CouncilKnut and Alice Wallenberg FoundationAvailable from: 2019-11-01 Created: 2019-11-01 Last updated: 2019-11-19Bibliographically approved

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Garoff, MariaAhlqvist, JanLevring Jäghagen, EvaWester, PerJohansson, Elias
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Department of OdontologyDepartment of Public Health and Clinical MedicineDepartment of Pharmacology and Clinical NeuroscienceClinical NeuroscienceWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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