Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Management of BK-virus infection - Swedish recommendations
Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.
Sahlgrens Univ Hosp, Dept Infect Dis, Gothenburg, Sweden.
Show others and affiliations
2019 (English)In: Infectious Diseases, ISSN 2374-4235, E-ISSN 2374-4243, Vol. 51, no 7, p. 479-484Article, review/survey (Refereed) Published
Abstract [en]

BK-virus (BKV) associated nephropathy (BKVAN) and BKV associated haemorrhagic cystitis (HC) are complications of BKV infection/reactivation in renal and allogeneic haematopoietic stem cell transplantation (HSCT) patients, respectively. The task of how to manage these diseases was given to the chair by the Swedish Reference Group for Antiviral Therapy (RAV). After individual contributions by members of the working group, consensus discussions were held in a meeting on 23 January 2018 arranged by RAV. Thereafter, the recommendations were published in Swedish on November 2018. The current translation to English has been approved by all co-authors. High BKV serum levels suggest an increased risk for BKVAN and potential graft failure. For detection of BKVAN, careful monitoring of BKV DNA levels in serum or plasma is recommended the first year after renal transplantation and when increased creatinine serum levels of unknown cause are observed. Notably, a renal biopsy is mandatory for diagnosis. To reduce the risk for progression of BKVAN, there is no specific treatment, and tailored individual decrease of immunosuppression is recommended. For BKV-HC, BKV monitoring is not recommended, since BK-viruria frequently occurs in HSCT patients and the predictive value of BKV in plasma/serum has not been determined. However, the risk for BKV-HC is higher for patients undergoing myeloablative conditioning, having an unrelated, HLA-mismatched, or a cord blood donor, and awareness of the increased risk and early intervention may benefit the patients. Also for BKV-HC, no specific therapy is available. Symptomatic treatment, e.g. forced diuresis and analgesics could be of use.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2019. Vol. 51, no 7, p. 479-484
Keywords [en]
BKV, transplantation, immunosuppression, haemorrhagic cystitis, BKVAN, management
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-396187DOI: 10.1080/23744235.2019.1595130ISI: 000469740800001PubMedID: 31012777OAI: oai:DiVA.org:uu-396187DiVA, id: diva2:1366800
Available from: 2019-10-30 Created: 2019-10-30 Last updated: 2019-10-30Bibliographically approved

Open Access in DiVA

fulltext(1417 kB)13 downloads
File information
File name FULLTEXT01.pdfFile size 1417 kBChecksum SHA-512
d4a27faa2e933fa8da5b64f62f4669e94a70f4c5670c165f597a4a2ccd7aed8ce0c30e3bf8e44ab1927e534f6a220b387d93f6acb10b5006467152ee8e10370a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Eriksson, Britt-Marie
By organisation
Infectious Diseases
In the same journal
Infectious Diseases
Infectious Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 13 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 38 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf