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Marine Natural Products: A Source of Novel Anticancer Drugs
Karolinska Univ Hosp, Clin Res Ctr, S-14157 Stockholm, Sweden;Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, SE-10691 Stockholm, Sweden.
Univ Kalamoon, Dept Lab Med, Fac Med, POB 222, Dayr Atiyah, Syria.
Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St,PB 11562, Cairo, Egypt;Amer Univ Cairo, Dept Chem, Sch Sci & Engn, New Cairo 11835, Egypt.
Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.
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2019 (English)In: Marine Drugs, ISSN 1660-3397, E-ISSN 1660-3397, Vol. 17, no 9, article id 491Article, review/survey (Refereed) Published
Abstract [en]

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 17, no 9, article id 491
Keywords [en]
marine, plants, microorganism, antitumor, anticancer, cytotoxic, clinical trials, drugs
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-395919DOI: 10.3390/md17090491ISI: 000487959700017PubMedID: 31443597OAI: oai:DiVA.org:uu-395919DiVA, id: diva2:1366683
Funder
Swedish Research Council, 2016-05885Available from: 2019-10-30 Created: 2019-10-30 Last updated: 2019-10-30Bibliographically approved

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