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Platelets as Key Factors in Hepatocellular Carcinoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2019 (English)In: Cancers, ISSN 2072-6694, Vol. 11, no 7, article id 1022Article, review/survey (Refereed) Published
Abstract [en]

Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in the setting of chronic inflammation and liver damage. The hepatic microenvironment plays a crucial role in the disease development, as players such as hepatic stellate cells, resident liver macrophages (Kupffer cells), endothelial cells, extracellular matrix, and a variety of immune cells interact in highly complex and intertwined signaling pathways. A key factor in these cross-talks are platelets, whose role in cancer has gained growing evidence in recent years. Platelets have been reported to promote HCC cell proliferation and invasion, but their involvement goes beyond the direct effect on tumor cells, as they are known to play a role in pro-fibrinogenic signaling and the hepatic immune response, as well as in mediating interactions between these factors in the stroma. Anti-platelet therapy has been shown to ameliorate liver injury and improve the disease outcome. However, platelets have also been shown to play a crucial role in liver regeneration after organ damage. Therefore, the timing and microenvironmental setting need to be kept in mind when assessing the potential effect and therapeutic value of platelets in the disease progression, while further studies are needed for understanding the role of platelets in patients with HCC.

Place, publisher, year, edition, pages
2019. Vol. 11, no 7, article id 1022
Keywords [en]
hepatocellular carcinoma, platelets, hemostasis, fibrosis, tumor-stroma interactions, hepatic stellate cells, macrophages
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-396001DOI: 10.3390/cancers11071022ISI: 000479322800132PubMedID: 31330817OAI: oai:DiVA.org:uu-396001DiVA, id: diva2:1366219
Funder
Swedish Cancer Society, CAN2017/518Swedish Cancer Society, CAN2013/1273Swedish Society for Medical Research (SSMF)Swedish Childhood Cancer FoundationAvailable from: 2019-10-28 Created: 2019-10-28 Last updated: 2019-10-28Bibliographically approved

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Pavlovic, NatasaRani, BhavnaGerwins, PärHeindryckx, Femke
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