Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells
Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.ORCID iD: 0000-0002-4793-4527
Menoufia Univ, Fac Sci, Chem Dept, Biochem Div, Shibin Al Kawm 32512, Egypt;Okayama Univ, Div Chem & Biotechnol, Grad Sch Nat Sci & Technol, Okayama 7008530, Japan.
Univ Sadat City, Genet Engn & Biotechnol Inst, Dept Mol Biol, Sadat City 32958, Egypt.
Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
Show others and affiliations
2019 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 24, no 18, article id 3313Article in journal (Refereed) Published
Abstract [en]

The current study aimed to synthesize new metal coordination complexes with potential biomedical applications. Metal complexes were prepared via the reaction of isatin-N(4)anti- pyrinethiosemicarbazone ligand 1 with Cu(II), Ni(II), Co(II), Zn(II), and Fe(III) ions. The obtained metal complexes 2-12 were characterized using elemental, spectral (H-1-NMR, EPR, Mass, IR, UV-Vis) and thermal (TGA) techniques, as well as magnetic moment and molar conductance measurements. In addition, their geometries were studied using EPR and UV-Vis spectroscopy. To evaluate the in vivo anti-cancer activities of these complexes, the ligand 1 and its metal complexes 2, 7 and 9 were tested against solid tumors. The solid tumors were induced by subcutaneous (SC) injection of Ehrlich ascites carcinoma (EAC) cells in mice. The impact of the selected complexes on the reduction of tumor volume was determined. Also, the expression levels of vascular endothelial growth factor (VEGF) and cysteine aspartyl-specific protease-7 (caspase-7) in tumor and liver tissues of mice bearing EAC tumor were determined. Moreover, their effects on alanine transaminase (ALT), aspartate transaminase (AST), albumin, and glucose levels were measured. The results revealed that the tested compounds, especially complex 9, reduced tumor volume, inhibited the expression of VEGF, and induced the expression of caspase-7. Additionally, they restored the levels of ALT, AST, albumin, and glucose close to their normal levels. Taken together, our newly synthesized metal complexes are promising anti-cancer agents against solid tumors induced by EAC cells as supported by the inhibition of VEGF and induction of caspase-7.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 24, no 18, article id 3313
Keywords [en]
metal complexes, isatin-N(4)antipyrinethiosemicarbazone, Ehrlich ascites carcinoma, tumor volume, VEGF, caspase-7
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-395850DOI: 10.3390/molecules24183313ISI: 000488830500105PubMedID: 31514445OAI: oai:DiVA.org:uu-395850DiVA, id: diva2:1365478
Funder
Swedish Research Council, 2016-05885Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2019-10-25Bibliographically approved

Open Access in DiVA

fulltext(2663 kB)21 downloads
File information
File name FULLTEXT01.pdfFile size 2663 kBChecksum SHA-512
ce4aca66d14c803527647b550dce22bd158819430c8088d384922c7bca9c105d08d5cd6b0eacd31ad86cf4ad3db9dda054802a43a4c2ab34b39018b86d17817c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
El-Saied, FathyEl-Seedi, Hesham
By organisation
Farmakognosi
In the same journal
Molecules
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 21 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 25 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf