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All-cause mortality in patients with treatment-resistant depression: a cohort study in the US population
Janssen Res & Dev, Real World Evidence Stat & Decis Sci, 920 US Highway 202 S, Raritan, NJ 08869 USA.
Janssen Res & Dev, Dept Epidemiol, 920 US Highway 202 S, Raritan, NJ 08869 USA.
Janssen Res & Dev, Real World Evidence Stat & Decis Sci, 920 US Highway 202 S, Raritan, NJ 08869 USA.
Janssen Sci Affairs LLC, Titusville, NJ USA.
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2019 (English)In: Annals of General Psychiatry, ISSN 1744-859X, E-ISSN 1744-859X, Vol. 18, no 1, article id 23Article in journal (Refereed) Published
Abstract [en]

Background Treatment-resistant depression (TRD) may represent a substantial proportion of major depressive disorder (MDD); however, the risk of mortality in TRD is still incompletely assessed. Methods Data were obtained from Optum Clinformatics (TM) Extended, a US claims database. Date of the first antidepressant (AD) dispensing was designated as the index date for study entry and 6 months prior to that was considered the baseline period. Patients with MDD aged >= 18 years, index date between January 1, 2008 and September 30, 2015, no AD claims during baseline, and continuous enrollment in the database during baseline were included. Patients who started a third AD regimen after two regimens of appropriate duration were included in the TRD cohort. All-cause mortality was compared between patients with TRD and non-TRD MDD using a proportional hazards model and Kaplan-Meier estimate with TRD status being treated as a time-varying covariate. The model was adjusted for study year, age, gender, depression diagnosis, substance use disorder, psychiatric comorbidities, and Charlson comorbidity index. Results Out of 355,942 patients with MDD, 34,176 (9.6%) met the criterion for TRD. TRD was associated with a significantly higher mortality compared with non-TRD MDD (adjusted HR: 1.29; 95% CI 1.22-1.38; p < 0.0001). Survival time was significantly shorter in the TRD cohort compared with the non-TRD MDD cohort (p < 0.0001). Conclusions Patients with TRD had a higher all-cause mortality compared with non-TRD MDD patients.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 18, no 1, article id 23
Keywords [en]
Major depressive disorder, Mortality, Treatment-resistant depression
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-395733DOI: 10.1186/s12991-019-0248-0ISI: 000488471800001PubMedID: 31583010OAI: oai:DiVA.org:uu-395733DiVA, id: diva2:1365083
Funder
Swedish Research Council, 2016-02362Available from: 2019-10-23 Created: 2019-10-23 Last updated: 2019-10-23Bibliographically approved

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