Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Endometriosis and cumulative live birth rate after fresh and frozen IVF cycles with single embryo transfer in young women: no impact beyond reduced ovarian sensitivity-a case control study
Karolinska Univ Hosp, Div Gynecol & Reprod, Dept Reprod Med, Novumhuset Plan 4, S-14186 Stockholm, Sweden;Wunschbaby Inst Feichtinger, Vienna, Austria;Med Univ Vienna, Div Gynecol Endocrinol & Reprod Med, Dept Obstet & Gynecol, Vienna, Austria;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.ORCID iD: 0000-0001-6453-9281
Karolinska Univ Hosp, Div Gynecol & Reprod, Dept Reprod Med, Novumhuset Plan 4, S-14186 Stockholm, Sweden.
Karolinska Univ Hosp, Div Gynecol & Reprod, Dept Reprod Med, Novumhuset Plan 4, S-14186 Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Show others and affiliations
2019 (English)In: Journal of Assisted Reproduction and Genetics, ISSN 1058-0468, E-ISSN 1573-7330, Vol. 36, no 8, p. 1649-1656Article in journal (Refereed) Published
Abstract [en]

Purpose To investigate the impact of symptomatic and surgically confirmed endometriosis on ovarian sensitivity index (OSI) and cumulative live-birth rates (LBR) using predominantly single embryo transfer (SET). Methods Cross-sectional case-control study in a University-based ART program. Women with symptomatic and surgically confirmed endometriosis (N = 172), who underwent IVF/ICSI at Karolinska University Hospital were compared to controls without clinically suspected endometriosis (N = 2585). Two thousand seven hundred fifty-seven patients underwent 8236 treatment cycles (4598 fresh and 3638 frozen cycles). Primary outcome measures included Ovarian Sensitivity Index (OSI) estimated as collected oocytes/FSH dose and cumulative LBR/oocyte pickup (OPU). Generalized estimated equation (GEE) model accounting for dependencies between consecutive treatments were applied. Secondary outcomes included number of oocytes, pregnancy rate per OPU and per ET, LBR per ET, and miscarriage rate. Results Patients diagnosed with endometriosis had significantly fewer oocytes collected (8.47 vs. 9.54, p = 0.015) and lower OSI (p = 0.011) than controls. There were no differences in cycle cancelations (p = 0.59) or miscarriages (p = 0.95) between the two groups. Cumulative LBR/OPU did not differ between women with endometriosis and controls (35.6% vs. 34.7%, respectively, p = 0.83). In both groups, more than 60% of women had consecutive FETs after fresh ETs (p = 0.49) with SET in > 70% of cases. The results were similar whether ovarian endometrioma was present or not. Conclusions Our data support that a diagnosis of endometriosis, with or without present endometrioma, does not negatively affect ART cumulative results. The impact of endometriosis was discernible on OSI but not on clinical relevant outcomes including pregnancy and LBR.

Place, publisher, year, edition, pages
SPRINGER/PLENUM PUBLISHERS , 2019. Vol. 36, no 8, p. 1649-1656
Keywords [en]
Endometriosis, Cumulative live-birth, Frozen-thawed, SET, Cumulative pregnancy rate
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-393901DOI: 10.1007/s10815-019-01519-5ISI: 000482952700014PubMedID: 31313013OAI: oai:DiVA.org:uu-393901DiVA, id: diva2:1362228
Available from: 2019-10-18 Created: 2019-10-18 Last updated: 2019-10-18Bibliographically approved

Open Access in DiVA

fulltext(326 kB)28 downloads
File information
File name FULLTEXT01.pdfFile size 326 kBChecksum SHA-512
6f583deb1e43ea18ee57c4599dc60c90c355e7f972cb4accb3762ce47d63a1b597a583fb87885e64e04897bd64781fe5f590478cd00fbf1ed30c2cbd503e2673
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Feichtinger, MichaelHadziosmanovic, NerminRodriguez-Wallberg, Kenny A.
By organisation
UCR-Uppsala Clinical Research Center
In the same journal
Journal of Assisted Reproduction and Genetics
Obstetrics, Gynecology and Reproductive Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 28 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 28 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf