Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Adhesive Cements That Bond Soft Tissue Ex Vivo
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Show others and affiliations
2019 (English)In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 12, no 15, article id 2473Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (alpha TCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. alpha TCP PMCs reached a final LSS of approximate to 110 kPa. In soft tissues, stronger bond strengths were obtained with alpha TCP PMCs containing large amounts of amino acid (70-90 mol%), in contrast to prior studies in calcified tissues (30-50 mol%). When alpha TCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30-50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 12, no 15, article id 2473
Keywords [en]
tissue adhesive, phosphoserine, phosphoserine modified cement, biomaterial, bioceramic, lap shear, bone cement, silicate, calcium phosphate, self-setting
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:uu:diva-393904DOI: 10.3390/ma12152473ISI: 000482576900134PubMedID: 31382566OAI: oai:DiVA.org:uu-393904DiVA, id: diva2:1362214
Funder
Swedish Research Council, RMA15-0110
Note

De två första författarna delar förstaförfattarskapet.

Available from: 2019-10-18 Created: 2019-10-18 Last updated: 2019-10-18Bibliographically approved

Open Access in DiVA

fulltext(2077 kB)45 downloads
File information
File name FULLTEXT01.pdfFile size 2077 kBChecksum SHA-512
3898d0a22f68a5afc293995e5ebb0a7d7fee05e17c10a35e9712fa8e1779d34c11d6b7cfe3301440723e65907f42db7ad962addaf06f960d1886075bd455aab2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Pujari-Palmer, MichaelWenner, DavidProcter, PhilipInsley, GerardEngqvist, Håkan
By organisation
Applied Materials Sciences
In the same journal
Materials
Medical Materials

Search outside of DiVA

GoogleGoogle Scholar
Total: 45 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 53 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf