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"Average is good, extremes are bad" - Non-linear inverted U-shaped relationship between neural mechanisms and functionality of mental features
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics. Hangzhou Normal Univ, Dept Psychol, Hangzhou 310013, Zhejiang, Peoples R China;Univ Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada.
Univ Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada.
2019 (English)In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 104, p. 11-25Article, review/survey (Refereed) Published
Abstract [en]

Traditionally, studies emphasize differences in neural measures between pathological and healthy groups, assuming a binary distinction between the groups, and a linear relationship between neural measures and symptoms. Here, we present four examples that show a continuous relation across the divide of normal and pathological states between neural measures and mental functions. This relation can be characterized by a nonlinear inverted-U shaped curve. Along this curve, mid-range or average expression of a neural measure is associated with optimal function of a mental feature (in healthy states), whereas extreme expression, either high or low, is associated with sub-optimal function, and occurs in different neural disorders. Neural expression between the optimal or intermediate and pathological or extreme values is associated with sub-optimal function and atrisk mental states. Thus, this model of neuro-mental relationship can be summarized as "average is good, extremes are bad". By focussing on neuro-mental relationships, this model can facilitate the transition of psychiatry from a categorical to a dimensional and individualized approach needed in the era of precision medicine.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2019. Vol. 104, p. 11-25
Keywords [en]
Optimal, Neuro-mental relationship, Inverted-U shape model, Psychiatric diagnosis, RDoC
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-394721DOI: 10.1016/j.neubiorev.2019.06.030ISI: 000483640500002PubMedID: 31251964OAI: oai:DiVA.org:uu-394721DiVA, id: diva2:1360150
Funder
EU, Horizon 2020, 785907Available from: 2019-10-11 Created: 2019-10-11 Last updated: 2019-10-11Bibliographically approved

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