The release of harmful chemicals into the Earth system is a threat to the survival of human societies and ecosystems. There are different types of harmful chemicals, some possess characteristics that are more harmful than others. Chemicals causing local effects have a short-term impact on the Earth system, whereas others are persistent in nature. The second becomes a global pollution issue because these substances accumulate, resulting in cascades through the Earth system. The chemical pollution issue is a scale challenge, meaning that the pollution issue occurs within and across levels and scales. Chemical pollution is not treated as a scale challenge in the decision-making process today. In the literature it is stated that chemical pollution is usually studied by focusing on single institutions, which hinders the possibility to investigate the linkages between the institutions affecting the scale dynamics. In this study the scale and cross-scale perspective was used to identify institutions that are affecting the work for a toxin free environment on a national and municipality level in Sweden. Governance Architecture was used as an analytical tool to investigate the key hindering and facilitating governance mechanisms to achieve sustainable chemical management in Sweden from a cross-scale perspective. The analytical tool was based on the Earth System Governance theory and scale dynamics. Sweden was used as a case to apply this tool. Two methods were used to gather empirics: literature analysis and in-depth interviews. The findings reveal an overrepresentation of the hindering factors being a result of a scale or a policy gap issue. These gaps are created by the lack of interdisciplinarity in the decision-making process, and the current legislation and politics which influences the implementation of the strategies on the different institutional levels. To overcome these hinders the current strategies and legislation needs to be in collaboration. This study contributes to empiric development within policy studies on how the chemical pollution issue needs to be conceptually formulated to achieve a toxin free environment within and cross-scales. It also contributes to method development by addressing the gap of including several institutions in cross-scale studies.