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Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix
Icahn Sch Med Mt Sinai, Dept Cell Dev & Regenerat Biol, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA;Swedish Res Council, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Icahn Sch Med Mt Sinai, Dept Cell Dev & Regenerat Biol, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA.
Icahn Sch Med Mt Sinai, Dept Cell Dev & Regenerat Biol, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA.
Icahn Sch Med Mt Sinai, Dept Cell Dev & Regenerat Biol, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, Annenberg Bldg 18-92,One Gustave L Levy Pl, New York, NY 10029 USA;CSL Behring, Keelung Rd, Taipei 110, Taiwan.
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2019 (English)In: Open Biology, ISSN 2046-2441, E-ISSN 2046-2441, Vol. 9, no 8, article id 190148Article in journal (Refereed) Published
Abstract [en]

Integrins mediate the anchorage between cells and their environment, the extracellular matrix (ECM), and form transmembrane links between the ECM and the cytoskeleton, a conserved feature throughout development and morphogenesis of epithelial organs. Here, we demonstrate that integrins and components of the ECM are required during the planar cell polarity (PCP) signalling-regulated cell movement of ommatidial rotation in the Drosophila eye. The loss-of-function mutations of integrins or ECM components cause defects in rotation, with mutant clusters rotating asynchronously compared to wild-type clusters. Initially, mutant clusters tend to rotate faster, and at later stages they fail to be synchronous with their neighbours, leading to aberrant rotation angles and resulting in a disorganized ommatidial arrangement in adult eyes. We further demonstrate that integrin localization changes dynamically during the rotation process. Our data suggest that core Frizzled/PCP factors, acting through RhoA and Rho kinase, regulate the function/activity of integrins and that integrins thus contribute to the complex interaction network of PCP signalling, cell adhesion and cytoskeletal elements required for a precise and synchronous 90 degrees rotation movement.

Place, publisher, year, edition, pages
ROYAL SOC , 2019. Vol. 9, no 8, article id 190148
Keywords [en]
planar cell polarity, Drosophila eye, ommatidial rotation, integrins, extracellular matrix
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-394163DOI: 10.1098/rsob.190148ISI: 000483917300006PubMedID: 31409231OAI: oai:DiVA.org:uu-394163DiVA, id: diva2:1357819
Available from: 2019-10-04 Created: 2019-10-04 Last updated: 2019-10-04Bibliographically approved

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