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Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville, Vic, Australia.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.ORCID iD: 0000-0002-8917-2612
Univ Sofia, Fac Chem & Pharm, Sofia, Bulgaria.
Univ Appl Sci & Arts Northwestern Switzerland, Inst Pharma Technol, Basel, Switzerland.
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2019 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 137, article id 104967Article in journal (Refereed) Published
Abstract [en]

Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.

Place, publisher, year, edition, pages
ELSEVIER , 2019. Vol. 137, article id 104967
Keywords [en]
Poorly water-soluble drugs, Formulation, Bioavailability, Drug delivery, Lipid formulations, Solid state
National Category
Pharmaceutical Sciences Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-393721DOI: 10.1016/j.ejps.2019.104967ISI: 000482085700028PubMedID: 31252052OAI: oai:DiVA.org:uu-393721DiVA, id: diva2:1356156
Available from: 2019-10-01 Created: 2019-10-01 Last updated: 2019-10-01Bibliographically approved

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Bergström, ChristelBrandl, MartinBauer-Brandl, Annette
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