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Combinations of Spok genes create multiple meiotic drivers in Podospora
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
Univ Bordeaux, Bordeaux, France.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
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2019 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e46454Article in journal (Refereed) Published
Abstract [en]

Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the Spok gene family underlies the Psks. The combination of Spok genes at different chromosomal locations defines the spore killer types and creates a killing hierarchy within a population. We identify two novel Spok homologs located within a large (74-167 kbp) region (the Spok block) that resides in different chromosomal locations in different strains. We confirm that the SPOK protein performs both killing and resistance functions and show that these activities are dependent on distinct domains, a predicted nuclease and kinase domain. Genomic and phylogenetic analyses across ascomycetes suggest that the Spok genes disperse through cross-species transfer, and evolve by duplication and diversification within lineages.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, article id e46454
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-391362DOI: 10.7554/eLife.46454ISI: 000477678700001PubMedID: 31347500OAI: oai:DiVA.org:uu-391362DiVA, id: diva2:1354039
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EU, Horizon 2020, ERC-2014-CoGSwedish Research CouncilAvailable from: 2019-09-24 Created: 2019-09-24 Last updated: 2019-09-24Bibliographically approved

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