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In Vitro Granuloma Models of Tuberculosis: Potential and Challenges
Univ Southampton, England.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-5092-9892
Florida Hosp Adventist Hlth Syst, FL USA.
NIAID, MD 20892 USA.
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2019 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 219, no 12, p. 1858-1866Article, review/survey (Refereed) Published
Abstract [en]

Despite intensive research efforts, several fundamental disease processes for tuberculosis (TB) remain poorly understood. A central enigma is that host immunity is necessary to control disease yet promotes transmission by causing lung immunopathology. Our inability to distinguish these processes makes it challenging to design rational novel interventions. Elucidating basic immune mechanisms likely requires both in vivo and in vitro analyses, since Mycobacterium tuberculosis is a highly specialized human pathogen. The classic immune response is the TB granuloma organized in three dimensions within extracellular matrix. Several groups are developing cell culture granuloma models. In January 2018, NIAID convened a workshop, entitled "3-D Human in vitro TB Granuloma Model" to advance the field. Here, we summarize the arguments for developing advanced TB cell culture models and critically review those currently available. We discuss how integrating complementary approaches, specifically organoids and mathematical modeling, can maximize progress, and conclude by discussing future challenges and opportunities.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC , 2019. Vol. 219, no 12, p. 1858-1866
Keywords [en]
granuloma; tuberculosis; tissue culture models
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-160445DOI: 10.1093/infdis/jiz020ISI: 000482350100002PubMedID: 30929010OAI: oai:DiVA.org:liu-160445DiVA, id: diva2:1353430
Note

Funding Agencies|Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Department of Health and Human Services [HHSN272201600001G]; Medical Research Council [MR/P023754/1]; NIH [1DP2HL127720-01, R33AI102239, UL1TR001070]; National Science Foundation [CMMI: 15-48571]; Swedish Research Council [2014-02289]

Available from: 2019-09-23 Created: 2019-09-23 Last updated: 2019-11-28

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