Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Relationship between endothelium-dependent vasodilation and fat distribution using the new "imiomics" image analysis technique
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.ORCID iD: 0000-0003-2335-8542
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.ORCID iD: 0000-0001-7764-1787
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.ORCID iD: 0000-0003-2815-1217
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. Antaros Med AB, BioVenture Hub, Mölndal, Sweden.
Show others and affiliations
2019 (English)In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 29, no 10, p. 1077-1086Article in journal (Refereed) Published
Abstract [en]

Background and aims: We investigated how vasoreactivity in the brachial artery and the forearm resistance vessels were related to fat distribution and tissue volume, using both traditional imaging analysis and a new technique, called “Imiomics”, whereby vasoreactivity was related to each of the >2M 3D image elements included in the whole-body magnetic resonance imaging (MRI).

Methods and results: In 326 subjects in the Prospective investigation of Obesity, Energy and Metabolism (POEM) study (all aged 50 years), endothelium-dependent vasodilation was measured by acetylcholine infusion in the brachial artery (EDV) and flow-mediated vasodilation (FMD). Fat distribution was evaluated by dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI). EDV, but not FMD, was significantly related to total fat mass, liver fat, subcutaneous (SAT) and visceral (VAT) adipose tissue in a negative fashion in women, but not in men. Using Imiomics, an inverse relationship was seen between EDV and a local tissue volume of SAT in both the upper part of the body, as well as the gluteo-femoral part and the medial parts of the legs in women. Also the size of the liver, heart and VAT was inversely related to EDV. In men, less pronounced relationships were seen. FMD was also significantly related to local tissue volume of upper-body SAT and liver fat in women, but less so in men.

Conclusion: EDV, and to a lesser degree also FMD, were related to liver fat, SAT and VAT in women, but less so in men. Imiomics both confirmed findings from traditional methods and resulted in new, more detailed results.

Place, publisher, year, edition, pages
2019. Vol. 29, no 10, p. 1077-1086
Keywords [en]
Magnetic resonance imaging, Whole body imaging, Image analysis, Atherosclerosis, Endothelial dysfunction, Obesity
National Category
Medical Image Processing Radiology, Nuclear Medicine and Medical Imaging
Research subject
Computerized Image Processing
Identifiers
URN: urn:nbn:se:uu:diva-392832DOI: 10.1016/j.numecd.2019.06.017ISI: 000484832100011PubMedID: 31377180OAI: oai:DiVA.org:uu-392832DiVA, id: diva2:1349965
Funder
Swedish Research Council, 2016-01040Swedish Heart Lung Foundation, 20170492Available from: 2019-06-24 Created: 2019-09-10 Last updated: 2019-10-11Bibliographically approved

Open Access in DiVA

fulltext(1955 kB)28 downloads
File information
File name FULLTEXT01.pdfFile size 1955 kBChecksum SHA-512
93cd48270068845accb70f5cf5b1349ff21f6e7bbbc5d06f2d6cc29cb39f46980c29909f1ea7a65caa70f214968cea3bebcd7a82c38deef4b53dc60aef94ca93
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lind, LarsStrand, RobinMichaëlsson, KarlKullberg, JoelAhlström, Håkan
By organisation
Clinical EpidemiologyRadiologyOrthopaedics
In the same journal
NMCD. Nutrition Metabolism and Cardiovascular Diseases
Medical Image ProcessingRadiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
Total: 28 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 37 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf