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Wnt signaling in intestinal inflammation
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences.
2019 (English)In: Differentiation, ISSN 0301-4681, E-ISSN 1432-0436, Vol. 108, p. 24-32Article, review/survey (Refereed) Published
Abstract [en]

Chronic inflammatory bowel diseases, including Crohns disease and ulcerative colitis, are a major health burden worldwide. Numerous conserved signaling pathways control tissue injury and repair during colitis, but owing to the complexity of the inflammatory process, their individual contribution remains poorly understood. A key regulatory pathway in the intestinal mucosa is Wnt/beta-catenin signaling, which acts as the central organizer of epithelial stem cell identity and maintenance. Apart from this core function, there is mounting evidence that the Wnt pathway is highly interconnected with numerous other signaling cascades, and that combinatorial signaling events shape epithelial homeostasis and tissue regeneration. Here we provide an updated view of how Wnt signaling intersects with major inflammatory pathways, with a particular focus on intestinal inflammation. Elucidating the reciprocal actions of Wnt ligands and cytokines has the potential to reveal new treatment options for chronic colitis and other inflammatory disorders.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2019. Vol. 108, p. 24-32
Keywords [en]
Cell signaling; IBD; STAT; NF-kappa B; AKT; MAPK; Interleukins
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-160174DOI: 10.1016/j.diff.2019.01.002ISI: 000481618600005PubMedID: 30718056OAI: oai:DiVA.org:liu-160174DiVA, id: diva2:1349569
Note

Funding Agencies|Knut and Alice Wallenberg Foundation (KAW); European Crohns and Colitis Organisation (ECCO), Austria; Ferring Pharmaceuticals, Switzerland

Available from: 2019-09-09 Created: 2019-09-09 Last updated: 2019-11-27

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