Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Seasonal Variation in Genome-Wide DNA Methylation Patterns and the Onset of Seasonal Timing of Reproduction in Great Tits
Univ Helsinki, Organismal & Evolutionary Biol Res Programme, Helsinki, Finland.
Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.
Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.
Univ Helsinki, Dept Math & Stat, Helsinki Inst Informat Technol HIIT, Helsinki, Finland;Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
Show others and affiliations
2019 (English)In: Genome Biology and Evolution, ISSN 1759-6653, E-ISSN 1759-6653, Vol. 11, no 3, p. 970-983Article in journal (Refereed) Published
Abstract [en]

In seasonal environments, timing of reproduction is a trait with important fitness consequences, but we know little about the molecular mechanisms that underlie the variation in this trait. Recently, several studies put forward DNA methylation as a mechanism regulating seasonal timing of reproduction in both plants and animals. To understand the involvement of DNA methylation in seasonal timing of reproduction, it is necessary to examine within-individual temporal changes in DNA methylation, but such studies are very rare. Here, we use a temporal sampling approach to examine changes in DNA methylation throughout the breeding season in female great tits (Parus major) that were artificially selected for early timing of breeding. These females were housed in climate-controlled aviaries and subjected to two contrasting temperature treatments. Reduced representation bisulfite sequencing on red blood cell derived DNA showed genome-wide temporal changes in more than 40,000 out of the 522,643 CpG sites examined. Although most of these changes were relatively small (mean within-individual change of 6%), the sites that showed a temporal and treatment-specific response in DNA methylation are candidate sites of interest for future studies trying to understand the link between DNA methylation patterns and timing of reproduction.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2019. Vol. 11, no 3, p. 970-983
Keywords [en]
DNA methylation, epigenetics, RRBS, Parus major, timing of reproduction, laying date
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-390286DOI: 10.1093/gbe/evz044ISI: 000476569300029PubMedID: 30840074OAI: oai:DiVA.org:uu-390286DiVA, id: diva2:1349424
Funder
EU, European Research Council, ERC-2013-AdG 339092Available from: 2019-09-09 Created: 2019-09-09 Last updated: 2019-09-09Bibliographically approved

Open Access in DiVA

fulltext(687 kB)30 downloads
File information
File name FULLTEXT01.pdfFile size 687 kBChecksum SHA-512
94280a7c4626c9ec3bee73a777ff689e1f6d2f43e62855258fa09682494ac03494840865bf30e58a0bd9f30b1e07ae9a0ae87642eab4abf992e161c917d9c883
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Husby, Arild
By organisation
Evolutionary Biology
In the same journal
Genome Biology and Evolution
Genetics

Search outside of DiVA

GoogleGoogle Scholar
Total: 30 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 45 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf