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Association between PD-1 and PD-L1 polymorphisms and the risk of cancer: a meta analysis of case-control studies
Zahedan University of Medical Sciences, Iran.
Zahedan University of Medical Sciences, Iran.
Zahedan University of Medical Sciences, Iran.
Iranshahr University of Medical Sciences, Iran.
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2019 (English)In: Cancers, ISSN 2072-6694, Vol. 11, no 8, article id 1150Article in journal (Refereed) Published
Abstract [en]

A number of case-control studies regarding the association of the polymorphisms in the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) genes with the risk of cancer have yielded inconsistent findings. Therefore, we have conducted a comprehensive, updated meta-analysis study to identify the impact of PD-1 and PD-L1 polymorphisms on overall cancer susceptibility. The findings revealed that PD-1 rs2227981 and rs11568821 polymorphisms significantly decreased the overall cancer risk (Odds Ratio (OR) = 0.82, 95% CI = 0.68–0.99, p = 0.04, TT vs. CT+CC; OR = 0.79, 95% CI = 0.67–0.94, p = 0.006, AG vs. GG, and OR = 0.82, 95% CI = 0.70–0.96, p = 0.020, AG+AA vs. GG, respectively), while PD-1 rs7421861 polymorphism significantly increased the risk of developing cancer (OR = 1.16, 95% CI = 1.02–1.33, p = 0.03, CT vs. TT). The PD-L1 rs4143815 variant significantly decreased the risk of cancer in homozygous (OR = 0.62, 95% CI = 0.41–0.94, p = 0.02), dominant (OR = 0.70, 95% CI = 0.50–0.97, p = 0.03), recessive (OR = 0.76, 95% CI = 0.60–0.96, p = 0.02), and allele (OR = 0.78, 95% CI = 0.63–0.96, p = 0.02) genetic models. No significant association between rs2227982, rs36084323, rs10204525, and rs2890658 polymorphisms and overall cancer risk has been found. In conclusions, the results of this meta-analysis have revealed an association between PD-1 rs2227981, rs11568821, rs7421861, as well as PD-L1 rs4143815 polymorphisms and overall cancer susceptibility. 

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 11, no 8, article id 1150
Keywords [en]
PD-1; PD-L1; apoptosis; cancer; meta-analysis; polymorphism
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-159931DOI: 10.3390/cancers11081150ISI: 000484438000110PubMedID: 31405171OAI: oai:DiVA.org:liu-159931DiVA, id: diva2:1346664
Note

Funding agencies: Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice; Research Manitoba New Investigators Operating Grant; CancerCare Manitoba Operating grant

Available from: 2019-08-28 Created: 2019-08-28 Last updated: 2019-09-30Bibliographically approved

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