Timber boards manufactured with a traditional sawing pattern often contain both heartwood andsapwood. In such boards, internal constraints can occur during drying because of a radial variation in greenstate(GS) MC between the heartwood (30-60%) and sapwood region (120-200%). Despite such knowledge,the initial MC is seldom considered when evaluating kiln-drying schedules. The effect of GS MC on thedevelopment of tangential tensile stress during drying is studied for four types of timber boards. A numericalmodel was developed that can simulate transient nonlinear orthotropic moisture flow and moisture–inducedstress and distortion in wood with the use of the finite element method. The stress analysis considers elastic,hygroscopic, and mechano-sorptive strain. The study shows that the GS MC does not significantly influencethe maximum stress state, but that it does influence the time at which the maximum tangential tensile stressoccurs at different exchange surfaces. This results in several periods in the drying schedule where unfavorablehigh stress situations in the tangential direction arise, which could lead to crack propagation.