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Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
Univ Florida, FL 32611 USA.
Univ Fed Pampa, Brazil.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
Univ Turku, Finland; Turku Univ Hosp, Finland.
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2019 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 3621Article in journal (Refereed) Published
Abstract [en]

Susceptibility to many human autoimmune diseases is under strong genetic control by class II human leukocyte antigen (HLA) allele combinations. These genes remain by far the greatest risk factors in the development of type 1 diabetes and celiac disease. Despite this, little is known about HLA influences on the composition of the human gut microbiome, a potential source of environmental influence on disease. Here, using a general population cohort from the All Babies in Southeast Sweden study, we report that genetic risk for developing type 1 diabetes autoimmunity is associated with distinct changes in the gut microbiome. Both the core microbiome and beta diversity differ with HLA risk group and genotype. In addition, protective HLA haplotypes are associated with bacterial genera Intestinibacter and Romboutsia. Thus, general population cohorts are valuable in identifying potential environmental triggers or protective factors for autoimmune diseases that may otherwise be masked by strong genetic control.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 10, article id 3621
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-159863DOI: 10.1038/s41467-019-11460-xISI: 000480234800002PubMedID: 31399563Scopus ID: 2-s2.0-85070578721OAI: oai:DiVA.org:liu-159863DiVA, id: diva2:1345946
Note

Funding Agencies|Barndiabetesfonden (Swedish Child Diabetes Foundation); Swedish Council for Working Life and Social Research [FAS2004-1775]; Swedish Research Council [K2005-72 x - 11242-11A, K2008-69 x - 20826-01-4]; Medical Research Council of Southeast Sweden (FORSS); JDRF Wallenberg Foundation [K 98-99D-12813-01A]; ALF grant from Region Ostergotland, Sweden; ALF grant from Linkoping University, Sweden; LfoU grant from Region Ostergotland, Sweden; LfoU grant from Linkoping University, Sweden; Ostgota Brandstodsbolag

Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2019-09-19Bibliographically approved

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Ördberg, MalinLudvigsson, Johnny
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Division of Children's and Women's healthFaculty of Medicine and Health SciencesH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala
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