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Depression and inflammation: The role of inflammatory biomarkers in the pathogenesis of depression
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2019 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

Depression är en sjukdom som drabbar människor i alla åldrar och kännetecknas av symptom som kronisk nedstämdhet och anhedoni. Forskning visar på att proinflammatoriska responser kan bidra till utvecklingen av depression genom att inverka på bland annat neurotransmission, neuronala banor och ge upphov till beteendeförändringar som kan bidra till utvecklingen av depression. Under normala förhållanden är inflammatoriska biomarkörer inblandade i processer nödvändiga för hälsan och ökad aktivitet är förknippat med immunförsvarets aktivitet vid infektion eller skada. Inflammatoriska processer är också förknippade med depression. Cytokiner som produceras i kroppen kan påverka hjärnan och hjärnan har kapacitet att producera cytokiner genom aktiverade mikrogliaceller. Metabolismen av neurotransmittorer kan störas genom inverkan av inflammatoriska cytokiner. Inflammatorisk aktivitet påverkar kopplingar och banor i hjärnan som har med sinnestämning, motivation och alarmsignaler att göra, förändringar som även ses hos deprimerade. Inflammation och depression delar flera genetiska och miljömässiga faktorer som gör vissa individer mer mottagliga för inflammationsmedierad depression, som i sin tur föreslås utgöra en subtyp av alla deprimerade. Nivån av inflammation i kroppen kan påverka resultatet av behandling vid depression. Ökad förståelse för processerna hos inflammationsmedierad depression kan ge upphov till nya potentiella behandlingsstrategier vid depression.

Abstract [en]

Depression is a mood disorder affecting people in all ages and symptoms are depressed mood and anhedonia. Research show that pro-inflammatory responses can contribute to the development of depression by influencing neurotransmission, neurocircuits and give rise to behaviour changes, and contribute to the development of depression. Inflammatory biomarkers are essential for maintaining health and increased levels is a result of immune system activation due to infection or injury. Inflammatory processes are also associated to depression. Cytokines produced in the body can affect the brain, which in turn has the capacity to produce cytokines through activated microglial cells. The metabolism of neurotransmitters can be disrupted by inflammatory cytokines. Inflammatory activity can affect connections and circuits in the brain related to mood, motivation and alarm signals, the same changes are also observed in depressed people. Inflammation and depression share genetic and environmental factors that make some individuals predisposed to inflammatory mediated depression, which is suggested to be a subtype of depression. The levels of inflammation in the body can affect the outcome of treatment in depression. Increased understanding of the underlying processes behind inflammation mediated depression can have the potential of new treatment strategies for depressive disorders.

Place, publisher, year, edition, pages
2019. , p. 39
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-88583OAI: oai:DiVA.org:lnu-88583DiVA, id: diva2:1345313
Subject / course
Biomedical Sciences
Educational program
Health Science Programme with Specialisation in Bio Sciences, 180 credits
Supervisors
Examiners
Available from: 2019-08-26 Created: 2019-08-23 Last updated: 2019-08-26Bibliographically approved

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