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Phylogenetic analysis and embryonic expression of panarthropod Dmrt genes
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.ORCID iD: 0000-0001-9007-4369
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.ORCID iD: 0000-0002-4026-4129
2019 (English)In: Frontiers in Zoology, ISSN 1742-9994, E-ISSN 1742-9994, Vol. 16, article id 23Article in journal (Refereed) Published
Abstract [en]

Background: One set of the developmentally important Doublesex and Male-abnormal-3 Related Transcription factors (Dmrt) is subject of intense research, because of their role in sex-determination and sexual differentiation. This likely non-monophyletic group of Dmrt genes is represented by the Drosophila melanogaster gene Doublesex (Dsx), the Caenorhabditis elegans Male-abnormal-3 (Mab-3) gene, and vertebrate Dmrt1 genes. However, other members of the Dmrt family are much less well studied, and in arthropods, including the model organism Drosophila melanogaster, data on these genes are virtually absent with respect to their embryonic expression and function.

Results: Here we investigate the complete set of Dmrt genes in members of all main groups of Arthropoda and a member of Onychophora, extending our data to Panarthropoda as a whole. We confirm the presence of at least four families of Dmrt genes (including Dsx-like genes) in Panarthropoda and study their expression profiles during embryogenesis. Our work shows that the expression patterns of Dmrt11E, Dmrt93B, and Dmrt99B orthologs are highly conserved among panarthropods. Embryonic expression of Dsx-like genes, however, is more derived, likely as a result of neo-functionalization after duplication.

Conclusions: Our data suggest deep homology of most of the panarthropod Dmrt genes with respect to their function that likely dates back to their last common ancestor. The function of Dsx and Dsx-like genes which are critical for sexual differentiation in animals, however, appears to be much less conserved.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 16, article id 23
Keywords [en]
Doublesex, Sexual differentiation, DMRT, Arthropoda, Panarthropoda, Onychophora, Tribolium, Parasteatoda, Glomeris, Euperipatoides, Neo-functionalization
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:uu:diva-391021DOI: 10.1186/s12983-019-0322-0ISI: 000474357500001PubMedID: 31303887OAI: oai:DiVA.org:uu-391021DiVA, id: diva2:1344224
Funder
Swedish Research Council, 621-2011-4703Available from: 2019-08-20 Created: 2019-08-20 Last updated: 2019-08-20Bibliographically approved

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Panara, VirginiaBudd, GrahamJanssen, Ralf
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