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Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.ORCID iD: 0000-0002-0151-8931
Univ Helsinki, Inst Biotechnol, Helsinki, Finland.
Univ Cambridge, Dept Zool, Cambridge, England;Univ Liverpool, Inst Integrat Biol, Liverpool, Merseyside, England;Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Liverpool, Merseyside, England.
Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
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2019 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 5, no 6, article id eaau3648Article in journal (Refereed) Published
Abstract [en]

Chromosome evolution presents an enigma in the mega-diverse Lepidoptera. Most species exhibit constrained chromosome evolution with nearly identical haploid chromosome counts and chromosome-level gene collinearity among species more than 140 million years divergent. However, a few species possess radically inflated chromosomal counts due to extensive fission and fusion events. To address this enigma of constraint in the face of an exceptional ability to change, we investigated an unprecedented reorganization of the standard lepidopteran chromosome structure in the green-veined white butterfly (Pieris napi). We find that gene content in P. napi has been extensively rearranged in large collinear blocks, which until now have been masked by a haploid chromosome number close to the lepidopteran average. We observe that ancient chromosome ends have been maintained and collinear blocks are enriched for functionally related genes suggesting both a mechanism and a possible role for selection in determining the boundaries of these genome-wide rearrangements.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2019. Vol. 5, no 6, article id eaau3648
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Genetics
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URN: urn:nbn:se:uu:diva-390648DOI: 10.1126/sciadv.aau3648ISI: 000473798500007PubMedID: 31206013OAI: oai:DiVA.org:uu-390648DiVA, id: diva2:1343779
Funder
Swedish Research Council, 2012-3715Swedish Research Council, 2010-5341Swedish Research Council, 621-2012-4001Knut and Alice Wallenberg Foundation, 2012.0058Academy of Finland, 131155Available from: 2019-08-19 Created: 2019-08-19 Last updated: 2019-08-19Bibliographically approved

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