Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Association of Maternal Age With Fetal Growth and Newborn Measures: The Mumbai Maternal Nutrition Project (MMNP)
Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton Gen Hosp, Tremona Rd, Southampton SO16 6YD, Hants, England.
Dr Joshi Imaging Clin, Mumbai, Maharashtra, India.
Ctr Study Social Change, Mumbai, Maharashtra, India.
Ctr Study Social Change, Mumbai, Maharashtra, India.
Show others and affiliations
2019 (English)In: Reproductive Sciences, ISSN 1933-7191, E-ISSN 1933-7205, Vol. 26, no 7, p. 918-927Article in journal (Refereed) Published
Abstract [en]

Background: Young maternal age is associated with poorer birth outcomes, but the mechanisms are incompletely understood. Using data from a prospective cohort of pregnant women living in Mumbai slums, India, we tested whether lower maternal age was associated with adverse fetal growth.

Methods: Fetal crown-rump length (CRL) was recorded at a median (interquartile range, IQR) of 10 weeks' gestation (9-10 weeks). Head circumference (HC), biparietal diameter (BPD), femur length (FL), and abdominal circumference (AC) were recorded at 19 (19-20) and 29 (28-30) weeks. Newborns were measured at a median (IQR) of 2 days (1-3 days) from delivery. Gestation was assessed using prospectively collected menstrual period dates.

Results: The sample comprised 1653 singleton fetuses without major congenital abnormalities, of whom 1360 had newborn measurements. Fetuses of younger mothers had smaller CRL (0.01 standard deviation [SD] per year of maternal age; 95% confidence interval CI: 0.00-0.02(1); P = .04), and smaller HC, FL, and AC at subsequent visits. Fetal growth of HC (0.04 cm; 95% CI: 0.02-0.05; P < .001), BPD (0.01 cm; 95% CI: 0.00-0.01; P = .009), FL (0.04 cm; 95% CI: 0.02-0.06; P < .001), and AC (0.01 cm; 95% CI: 0.00-0.01; P = .003) up to the third trimester increased with maternal age. Skinfolds, head, and mid-upper arm circumferences were smaller in newborns of younger mothers. Adjusting for maternal prepregnancy socioeconomic status, body mass index, height, and parity attenuated the associations between maternal age and newborn size but did not change those with fetal biometry.

Conclusion: Fetuses of younger mothers were smaller from the first trimester onward and grew slower, independently of known confounding factors.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS INC , 2019. Vol. 26, no 7, p. 918-927
Keywords [en]
fetal biometry, ultrasound, maternal age, pregnancy, newborn, India
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-391028DOI: 10.1177/1933719118799202ISI: 000475782200006PubMedID: 30419799OAI: oai:DiVA.org:uu-391028DiVA, id: diva2:1343707
Funder
Wellcome trust, WT074048Available from: 2019-08-19 Created: 2019-08-19 Last updated: 2019-08-19Bibliographically approved

Open Access in DiVA

fulltext(403 kB)66 downloads
File information
File name FULLTEXT01.pdfFile size 403 kBChecksum SHA-512
8791b054eafc8da4c3ce33b68aeffad775db6f08ac7c7435483bf96ed730d17030aa9b75a331318abe8a75cb1d91b3d3e5c4642228b8d6edc257804afa91ba35
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Brown, Nick
By organisation
International Child Health and Nutrition
In the same journal
Reproductive Sciences
Obstetrics, Gynecology and Reproductive Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 66 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 71 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf