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Cemented injectable multi-phased porous bone grafts for the treatment of femoral head necrosis
Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China;Peking Union Med Coll, Beijing 100730, Peoples R China.
Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China;Peking Union Med Coll, Beijing 100730, Peoples R China.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.ORCID iD: 0000-0003-2709-9541
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2019 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 7, no 18, p. 2997-3006Article in journal (Refereed) Published
Abstract [en]

Femoral head necrosis (FHN) can induce musculoskeletal disability. It presents a challenge from diagnostic and therapeutic points of view. Open surgery for the treatment of FHN is not an optimal route. To minimize the surgery window, an injectable material with a porous structure and bioactive nature is preferred. The fabrication of an injectable porous bone graft via a simple route was the aim of our study. Therefore, cemented multi-phased calcium phosphate porous granules have been studied with varied phase compositions, pore sizes and porosities, and degradation rates. Granules templated by PEG 100-600 mu m were chosen for cell toxicity and in vitro osteogenic potential testing. Rabbits, making up a femoral head necrosis model, were implanted with granule A. Mature cancellous bone tissue was observed in the femoral head defect after 2 months implantation. The results indicate that the newly formed injectable bioactive porous grafts could be a good candidate for the treatment of femoral head necrosis.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2019. Vol. 7, no 18, p. 2997-3006
National Category
Orthopaedics
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URN: urn:nbn:se:uu:diva-390518DOI: 10.1039/c9tb00238cISI: 000472921600011OAI: oai:DiVA.org:uu-390518DiVA, id: diva2:1342722
Available from: 2019-08-14 Created: 2019-08-14 Last updated: 2019-08-14Bibliographically approved

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