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Exercise training alters lipoprotein particles independent of brown adipose tissue metabolic activity
Univ Turku, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland.
Univ Turku, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland;Turku Univ Hosp, Dept Med Phys, Turku, Finland.
Univ Turku, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland.
Univ Turku, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland;Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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2019 (English)In: OASE : tijdschrift voor architectuur, ISSN 2451-8476, E-ISSN 2055-2238, Vol. 5, no 3, p. 258-272Article in journal (Refereed) Published
Abstract [en]

Introduction New strategies for weight loss and weight maintenance in humans are needed. Human brown adipose tissue (BAT) can stimulate energy expenditure and may be a potential therapeutic target for obesity and type 2 diabetes. However, whether exercise training is an efficient stimulus to activate and recruit BAT remains to be explored. This study aimed to evaluate whether regular exercise training affects cold-stimulated BAT metabolism and, if so, whether this was associated with changes in plasma metabolites. Methods Healthy sedentary men (n = 11; aged 31 [SD 7] years; body mass index 23 [0.9] kg m(-2); VO2 max 39 [7.6] mL min(-1) kg(-1)) participated in a 6-week exercise training intervention. Fasting BAT and neck muscle glucose uptake (GU) were measured using quantitative [F-18]fluorodeoxyglucose positron emission tomography-magnetic resonance imaging three times: (1) before training at room temperature and (2) before and (3) after the training period during cold stimulation. Cervico-thoracic BAT mass was measured using MRI signal fat fraction maps. Plasma metabolites were analysed using nuclear magnetic resonance spectroscopy. Results Cold exposure increased supraclavicular BAT GU by threefold (p < 0.001), energy expenditure by 59% (p < 0.001) and plasma fatty acids (p < 0.01). Exercise training had no effect on cold-induced GU in BAT or neck muscles. Training increased aerobic capacity (p = 0.01) and decreased visceral fat (p = 0.02) and cervico-thoracic BAT mass (p = 0.003). Additionally, training decreased very low-density lipoprotein particle size (p = 0.04), triglycerides within chylomicrons (p = 0.04) and small high-density lipoprotein (p = 0.04). Conclusions Although exercise training plays an important role for metabolic health, its beneficial effects on whole body metabolism through physiological adaptations seem to be independent of BAT activation in young, sedentary men.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 5, no 3, p. 258-272
Keywords [en]
Brown adipose tissue, exercise training, glucose uptake, nor-epinephrine, positron emission tomography
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-390601DOI: 10.1002/osp4.330ISI: 000472584400008PubMedID: 31275600OAI: oai:DiVA.org:uu-390601DiVA, id: diva2:1342308
Funder
Academy of Finland, 307402Academy of Finland, 292839Academy of Finland, 269977Available from: 2019-08-13 Created: 2019-08-13 Last updated: 2019-08-13Bibliographically approved

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