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Evaluation of C. diff Quik Chek Complete® and comparison with GeneXpert to establish a new diagnostic algorithm
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
2018 (Swedish)Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Clostridium difficile is the most common antibiotic related diarrhéa disease in Sweden. New recommendations from the Swedish public health authority and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) had led to that a more advanced diagnostic algorithm is of priority. Hence this study, whose purpose was to investigate whether the performance of the rapid test C. diff Quik Chek Complete® could enable the introduction of a new diagnostic algorithm for detection of toxin-forming C. difficile in laboratory medicine in Sundsvall, according to these new recommendations. In the study 119 patient stool-samples were analysed with both GeneXpert and C. diff Quik Chek Complete® and these two combined fulfils these new recommendations of detecting toxin A and B from toxigenic C. difficile together with the enzyme Glutamate Dehydrogenase (GDH) which is produced by all C. difficile stems. The results shows that C. diff Quik Chek Complete® is well matched with GeneXpert and that most of the samples would come to be answered immediately after analysis with C. diff Quik Chek Complete®. The laboratory will save both time and money to establish C. diff Quik Chek Complete® in their algorithm for diagnosing C. difficile infection.

Place, publisher, year, edition, pages
2018. , p. 15
Keywords [en]
Clostridium difficile infection, toxin A, toxin B, glutamat dehydrogenase, antibiotic resistance, Enzyme Immuo Assay
National Category
Natural Sciences Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-390609OAI: oai:DiVA.org:uu-390609DiVA, id: diva2:1342134
Educational program
Biomedical Laboratory Science Programme; Biomedical Laboratory Science Programme
Supervisors
Examiners
Available from: 2019-08-21 Created: 2019-08-12 Last updated: 2019-08-21Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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Output format
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