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Potentiellt cancerpreventiva effekter av Sulforafan: En litteraturstudie
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2019 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

Sulforafan är en isotiacyanat som beskrivs ha effektiva cancerpreventativa egenskaper. Kemikalien görs tillgänglig för människan genom konsumtion av korsblommiga grönsaker så som broccoli och grönkål. Cancer är vanligt, och i Sverige räknar man med att var tredje människa kommer att drabbas under sin livstid. I följande litteraturstudie var syftet att sammanställa information om på vilket sätt sulforafan påverkar koloncancerceller, samt söka evidens för att konsumtion av sulforafanrika grönsaker bidrar till minskad risk att drabbas av koloncancer. Sulforafan har cancerpreventativa egenskaper i cellkultur så som inhibering av histondeacetylas-aktivitet, inducering av cellcykelarrest och apoptos och minskad proliferation hos cancercellerna. Det minskar även uttryck av gener som är inblandade i angiogenes.Det finns inte nog med evidens om broccolikonsumtion, på grund av sitt höga innehåll av sulforafan, skulle vara cancerpreventativt hos människan.

Abstract [en]

Sulforaphane is an isothiocyanate that is described as having chemopreventative effects. The phytochemical is made available to humans by dietary consumption of cruciferous vegetables such as broccoli and kale. Cancer is a common disease, and in Sweden it is estimated that one in three will be diagnosed with cancer during their lifetime. This review study aims to summarize the effect of sulforaphane on human colon cancer cells, and seek evidence that consumption of cruciferous vegetables reduces the risk of developing colon cancer. Sulforaphane is considered chemopreventative in vitro through inhibition of histone deacetylas activity, induction of cell cycle arrest and apoptosis and through reduction of cell proliferation. It has also been shown to reduces expression of genes involved in angiogenesis.There is not enough evidence to confirm that dietary broccoli consumption, through its high content of sulforaphane, would be chemopreventative.

Place, publisher, year, edition, pages
2019. , p. 23
Keywords [en]
Sulforafan, chemoprevention, colon cancer
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:lnu:diva-87516OAI: oai:DiVA.org:lnu-87516DiVA, id: diva2:1342123
Educational program
Health Science Programme with Specialisation in Bio Sciences, 180 credits
Supervisors
Examiners
Available from: 2019-08-15 Created: 2019-08-12 Last updated: 2019-08-15Bibliographically approved

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