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Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Stockholm, Sweden.ORCID iD: 0000-0002-6163-9540
NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab. Natl Bioinformat Infrastruct, Dept Med Sci, Uppsala, Sweden.ORCID iD: 0000-0003-0226-1047
Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Stockholm, Sweden;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden.
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2019 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e43578Article in journal, Editorial material (Other academic) Published
Abstract [en]

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, article id e43578
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Immunology in the medical area
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URN: urn:nbn:se:uu:diva-390333DOI: 10.7554/eLife.43578ISI: 000473150200001PubMedID: 31244471OAI: oai:DiVA.org:uu-390333DiVA, id: diva2:1341675
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Swedish Research Council FormasSwedish Research CouncilKnut and Alice Wallenberg FoundationNovo NordiskSwedish Society for Medical Research (SSMF)Available from: 2019-08-09 Created: 2019-08-09 Last updated: 2019-08-09Bibliographically approved

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