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Unsurpassed Intrahepatic Islet Engraftment: the Quest for New Sites for Beta Cell Replacement
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.ORCID iD: 0000-0003-4804-5091
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.ORCID iD: 0000-0001-8843-7941
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.
2019 (English)In: Cell Medicine, ISSN 2155-1790, E-ISSN 2155-1790, Vol. 11, article id 2155179019857662Article in journal, Editorial material (Other academic) Published
Abstract [en]

The liver is currently the site of choice for clinical islet transplantation, even though many alternative implantation sites have lately been proposed as more ideal for graft survival. The suggested sites, for example intramuscular space, omentum, bone marrow, and spleen, are sometimes difficult to compare due to differences in animal model, islet isolation procedure, and islet quality. In addition, the variation in transplanted islet mass is vast. The aim of this commentary is to review alternative implantation sites tested experimentally as well as in clinical islet transplantation. Although many sites have been investigated, none have convincingly proved better suited for clinical islet transplantation than intraportal injection to the liver, regardless of whether it is autologous or allogeneic transplantation. However, in order to fully evaluate upcoming bioengineering techniques, such as scaffolds containing insulin-producing cells derived from stem cells, the need of an alternative site has arisen to enable cellular monitoring, which currently cannot be achieved within the liver.

Place, publisher, year, edition, pages
Sage Publications, 2019. Vol. 11, article id 2155179019857662
Keywords [en]
intraportal islet transplantation, type 1 diabetes, beta cell replacement
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-390334DOI: 10.1177/2155179019857662ISI: 000472913100001OAI: oai:DiVA.org:uu-390334DiVA, id: diva2:1341642
Available from: 2019-08-09 Created: 2019-08-09 Last updated: 2019-08-09Bibliographically approved

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