Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Mitotically heritable effects of BMAA on striatal neural stem cell proliferation and differentiation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Stockholm Univ, Dept Environm Sci & Analyt Chem, Sci Life Lab, S-11418 Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Stockholm Univ, Dept Environm Sci & Analyt Chem, Sci Life Lab, S-11418 Stockholm, Sweden.
2019 (English)In: Cell Death and Disease, ISSN 2041-4889, E-ISSN 2041-4889, Vol. 10, article id 478Article in journal (Refereed) Published
Abstract [en]

The widespread environmental contaminant beta-methylamino-L-alanine (BMAA) is a developmental neurotoxicant that can induce long-term learning and memory deficits. Studies have shown high transplacental transfer of 3H-BMAA and a significant uptake in fetal brain. Therefore, more information on how BMAA may influence growth and differentiation of neural stem cells is required for assessment of the risk to the developing brain. The aim of this study was to investigate direct and mitotically inherited effects of BMAA exposure using primary striatal neurons and embryonic neural stem cells. The neural stem cells were shown to be clearly more susceptible to BMAA exposure than primary neurons. Exposure to 250 mu M BMAA reduced neural stem cell proliferation through apoptosis and G2/M arrest. At lower concentrations (50-100 mu M), not affecting cell proliferation, BMAA reduced the differentiation of neural stem cells into astrocytes, oligodendrocytes, and neurons through glutamatergic mechanisms. Neurons that were derived from the BMAA-treated neuronal stem cells demonstrated morphological alterations including reduced neurite length, and decreased number of processes and branches per cell. Interestingly, the BMAA-induced changes were mitotically heritable to daughter cells. The results suggest that early-life exposure to BMAA impairs neuronal stem cell programming, which is vital for development of the nervous system and may result in long-term consequences predisposing for both neurodevelopmental disorders and neurodegenerative disease later in life. More attention should be given to the potential adverse effects of BMAA exposure on brain development.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 10, article id 478
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:uu:diva-390201DOI: 10.1038/s41419-019-1710-2ISI: 000472438300009PubMedID: 31209203OAI: oai:DiVA.org:uu-390201DiVA, id: diva2:1341529
Funder
Swedish Research CouncilSwedish Research Council FormasAvailable from: 2019-08-09 Created: 2019-08-09 Last updated: 2019-08-09Bibliographically approved

Open Access in DiVA

fulltext(9136 kB)50 downloads
File information
File name FULLTEXT01.pdfFile size 9136 kBChecksum SHA-512
ff9f3d4ad568af6bf925ebe9ad9277d73e68eff612bf57dc770ffed62afecb663db0fcdf7debeedf72bf10864da1fb36723cf309063aa237833848decfd8d57b
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Pierozan, PaulaKarlsson, Oskar
By organisation
Department of Pharmaceutical Biosciences
In the same journal
Cell Death and Disease
Developmental Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 50 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 62 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf