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Pupil dilation to emotional expressions in adolescent social anxiety disorder is related to treatment outcome
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.ORCID iD: 0000-0001-8222-1699
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.ORCID iD: 0000-0002-5313-8498
2019 (English)In: Journal of Anxiety Disorders, ISSN 0887-6185, E-ISSN 1873-7897, Vol. 65, p. 26-33Article in journal (Refereed) Published
Abstract [en]

Atypical attention to potential social threats, such as emotional faces, may be one of the core mechanisms underlying social anxiety disorder (SAD). Pupil dilation is an index of locus coreuleus-noradrenergic activity, and closely linked to attention. In the present study, pupil dilation was studied in adolescents with SAD (N = 26; 22 Female) before the onset of a 12-week cognitive behavioral treatment, and in healthy controls (N = 23). Stimuli were faces with angry or happy emotional expressions. Contrary to our hypothesis, the SAD group did not show hyper-responsiveness to angry compared to happy faces. Instead, an atypical time course of the pupil dilation response was found, resulting in an attenuated response during late time stages. Larger pupil dilation amplitude to happy faces before treatment was related to worse treatment response. These results contribute significantly to our understanding of the mechanisms underlying adolescent SAD.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2019. Vol. 65, p. 26-33
Keywords [en]
Social anxiety disorder, Pupil dilation, Noradrenaline, Cognitive behavioral therapy (CBT)
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-390218DOI: 10.1016/j.janxdis.2019.04.006ISI: 000472239200004PubMedID: 31136877OAI: oai:DiVA.org:uu-390218DiVA, id: diva2:1340991
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and Welfare, Forte 2014-4052Forte, Swedish Research Council for Health, Working Life and Welfare, 2014-4052Stockholm County Council, PPG 20150032Available from: 2019-08-07 Created: 2019-08-07 Last updated: 2019-08-07Bibliographically approved

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