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Design of Multi-function Polymeric Nanoparticles for Theranostic Application
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH). (coating technology division)
2019 (English)Independent thesis Advanced level (degree of Master (Two Years)), 80 credits / 120 HE creditsStudent thesisAlternative title
Design av multifunktionella polymera nanopartiklar för teranostisk tillämpning (Swedish)
Abstract [en]

Block copolymer nanoparticles (NPs) have gained great attention among researcher for various medical application mainly due to their extraordinary optical, chemical, and biological properties. The current thesis presents design of multifunctional polymeric NPs for imaging and drug delivery system (DDS) with an in-vitro study of their participation in drug release and cell viability. The NPs were synthesized using reversible addition chain fragmentation transfer (RAFT)-mediated emulsion polymerization via polymerization induce self-assembly (PISA) approach. The environment-friendly emulsion polymerization process of n-buytl acrylate (n-BA) in water is highly efficient. The process produced uniform NPs which would have control over the particle size and molecular weight of the compound. Herein we report a novel simultaneous encapsulation of camptothecin (CPT) and Nile red (NR) into poly(ethylene glycol) methyl ether methacrylate-co-N-hydroxyethyl acrylamide-b-poly n-buytlacrylate (PEGA-co-HEAA)-b-P(n-BA) during the particles formation with a small particle size of 66 nm, high conversion ~80% and encapsulation efficiency of ~50%. The In vitro drug release of the CPT from the NPs exhibited an initial burst (70-80%) within 6h. cell viability was evaluated for the NPs against RAW 264.7 cell line, which indicated the designed NPs are biocompatible and not toxic.

 

Place, publisher, year, edition, pages
2019. , p. 40
Series
TRITA-CBH-GRU ; 2019:086
Keywords [en]
theranostic, polymeric nanparticles, drug delivery, camptothecin, nile red, encapsulation during particle formation
National Category
Medical and Health Sciences Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-255348OAI: oai:DiVA.org:kth-255348DiVA, id: diva2:1339368
Subject / course
Medical Engineering
Educational program
Master of Science - Medical Engineering
Presentation
2019-06-04, stockholm, 12:16 (English)
Supervisors
Examiners
Available from: 2019-07-29 Created: 2019-07-29 Last updated: 2019-07-29Bibliographically approved

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fulltext(2154 kB)14 downloads
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Citation style
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