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Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics
KTH Royal Inst Technol, Dept Fibre & Polymer Technol, SE-10044 Stockholm, Sweden.
KTH Royal Inst Technol, Dept Fibre & Polymer Technol, SE-10044 Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.ORCID iD: 0000-0001-5626-3959
KTH Royal Inst Technol, Dept Fibre & Polymer Technol, SE-10044 Stockholm, Sweden.
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2019 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 29, no 18, article id 1806693Article in journal (Refereed) Published
Abstract [en]

A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly of allyl-functional polyesters based on dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiols via UV initiated off-stoichiometric thiol-ene chemistry. The facile approach enabled multigram creation of allyl reactive nanogel precursors, in the size range of 190-295 nm, being readily available for further modifications to display a number of core functionalities while maintaining the size distribution and characteristics of the master batch. The nanogels are evaluated as carriers of a spread of chemotherapeutics by customizing the core to accommodate each individual cargo. The resulting nanogels are biocompatible, displaying diffusion controlled release of cargo, maintained therapeutic efficacy, and decreased cargo toxic side effects. Finally, the nanogels are found to successfully deliver pharmaceuticals into a 3D pancreatic spheroids tumor model.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2019. Vol. 29, no 18, article id 1806693
Keywords [en]
cancer treatment, dendritic nanogel, drug delivery, nanomedicine
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-389829DOI: 10.1002/adfm.201806693ISI: 000471330500004OAI: oai:DiVA.org:uu-389829DiVA, id: diva2:1339362
Funder
Knut and Alice Wallenberg Foundation, 2012-0196EU, FP7, Seventh Framework Programme, 60418Swedish Childhood Cancer Foundation, TJ2017-0009Swedish Research Council, 2010-453Available from: 2019-07-29 Created: 2019-07-29 Last updated: 2019-07-29Bibliographically approved

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