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Hyperspectral imaging in the spatial frequency domain with a supercontinuum source.
Beckman Laser Institute and Medical Clinic, United States.; Univ. of California, Irvine, United States..
Colorado State Univ., United States..
Beckman Laser Institute and Medical Clinic, United States..
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
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2019 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 24, no 7, p. StartPage-EndPageArticle in journal (Refereed) Published
Abstract [en]

We introduce a method for quantitative hyperspectral optical imaging in the spatial frequency domain (hs-SFDI) to image tissue absorption (μa) and reduced scattering (μs') parameters over a broad spectral range. The hs-SFDI utilizes principles of spatial scanning of the spectrally dispersed output of a supercontinuum laser that is sinusoidally projected onto the tissue using a digital micromirror device. A scientific complementary metal-oxide-semiconductor camera is used for capturing images that are demodulated and analyzed using SFDI computational models. The hs-SFDI performance is validated using tissue-simulating phantoms over a range of μa and μs' values. Quantitative hs-SFDI images are obtained from an ex-vivo beef sample to spatially resolve concentrations of oxy-, deoxy-, and met-hemoglobin, as well as water and fat fractions. Our results demonstrate that the hs-SFDI can quantitatively image tissue optical properties with 1000 spectral bins in the 580- to 950-nm range over a wide, scalable field of view. With an average accuracy of 6.7% and 12.3% in μa and μs', respectively, compared to conventional methods, hs-SFDI offers a promising approach for quantitative hyperspectral tissue optical imaging.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2019. Vol. 24, no 7, p. StartPage-EndPage
National Category
Radiology, Nuclear Medicine and Medical Imaging
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URN: urn:nbn:se:liu:diva-159115DOI: 10.1117/1.JBO.24.7.071614ISI: 000481886200017OAI: oai:DiVA.org:liu-159115DiVA, id: diva2:1339301
Note

Funding agencies:  National Institute of Health (NIH) NIBIB Biomedical Technology Research Center LAMMP [P41EB015890]; NIH [R21EB020953]; Military Medical Photonics Program: AFOSR [FA9550-17-1-0193]; Arnold and Mabel Beckman Foundation

Available from: 2019-07-29 Created: 2019-07-29 Last updated: 2019-09-09

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Saager, Rolf
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