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Tools of Aggregatibacter actinomycetemcomitans to Evade the Host Response
Umeå University, Faculty of Medicine, Department of Odontology. (Aa-gruppen)ORCID iD: 0000-0002-7948-9464
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology. (Aa-gruppen)
Umeå University, Faculty of Medicine, Department of Odontology. (Aa-gruppen)
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2019 (English)In: Journal of Clinical Medicine, ISSN 2077-0383, Vol. 8, no 7, article id 1079Article in journal (Refereed) Published
Abstract [en]

Periodontitis is an infection-induced inflammatory disease that affects the tooth supporting tissues, i.e., bone and connective tissues. The initiation and progression of this disease depend on dysbiotic ecological changes in the oral microbiome, thereby affecting the severity of disease through multiple immune-inflammatory responses. Aggregatibacter actinomycetemcomitans is a facultative anaerobic Gram-negative bacterium associated with such cellular and molecular mechanisms associated with the pathogenesis of periodontitis. In the present review, we outline virulence mechanisms that help the bacterium to escape the host response. These properties include invasiveness, secretion of exotoxins, serum resistance, and release of outer membrane vesicles. Virulence properties of A. actinomycetemcomitans that can contribute to treatment resistance in the infected individuals and upon translocation to the circulation, also induce pathogenic mechanisms associated with several systemic diseases.

Place, publisher, year, edition, pages
Basel: MDPI, 2019. Vol. 8, no 7, article id 1079
Keywords [en]
Aggregatibacter actinomycetemcomitans, cytolethal distending toxin, invasiveness, leukotoxin, outer membrane vesicles, serum resistance
National Category
Medical Biotechnology
Research subject
Infectious Diseases
Identifiers
URN: urn:nbn:se:umu:diva-161754DOI: 10.3390/jcm8071079PubMedID: 31336649OAI: oai:DiVA.org:umu-161754DiVA, id: diva2:1339132
Available from: 2019-07-25 Created: 2019-07-25 Last updated: 2019-07-29Bibliographically approved

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Oscarsson, JanClaesson, RolfLindholm, MarkHöglund-Åberg, CarolaJohansson, Anders
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