Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Quantitative organization of the excitatory synapses of the primate cerebellar nuclei: further evidence for a specialized architecture underlying the primate cerebellum
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
2019 (English)In: Brain Structure and Function, ISSN 1863-2653, E-ISSN 1863-2661, Vol. 224, no 6, p. 1987-1998Article in journal (Refereed) Published
Abstract [en]

The cerebellar intrinsic connectivity is of remarkable regularity with a similar build repeated many times over. However, several modifications of this basic circuitry occur that can provide important clues to evolutionary adaptations. We have observed differences in the wiring of the cerebellar output structures (the deep cerebellar nuclei, DCN) with higher dendritic length density in the phylogenetically newer DCN. In rats, we showed that an increase in wiring is associated with an increase in the presynaptic vesicular glutamate transporter 1 (vGluT1). In this study, we have extended our analysis to the rhesus monkey and can show similarities and differences between the two species. The similarities confirm a higher density in vGluT1+ boutons in the lateral (LN/dentate) and posterior interpositus nucleus compared to the phylogenetically older DCN. In general, we also observe a lower density of vGluT1 and 2+boutons in the monkey, which however, yields a similar number of excitatory boutons per neuron in both species. The only exception is the vGlut1+boutons in the macaque LN/dentate, which showed a significantly lower number of vGluT1+boutons per neuron. We also detected a higher percentage of co-labelled vGluT1 and 2 boutons in the macaque than we found in the rat. In summary, these results confirm that the hyposcalled dendrites of the monkey LN/dentate also show a lower number of vGluT1+boutons per neuron. These results provide further support of our model relating the dendritic morphology of the LN/dentate neurons to the morphology of the specially enlarged LN/dentate nucleus in primates.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2019. Vol. 224, no 6, p. 1987-1998
Keywords [en]
Vesicular glutamate transporter, Lipofuscin fluorescence removal, Deep cerebellar nuclei, Quantitative immunofluorescence, Comparative neuroanatomy
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-161575DOI: 10.1007/s00429-019-01888-8ISI: 000472887900002PubMedID: 31101974OAI: oai:DiVA.org:umu-161575DiVA, id: diva2:1338959
Available from: 2019-07-25 Created: 2019-07-25 Last updated: 2019-07-25Bibliographically approved

Open Access in DiVA

fulltext(2366 kB)66 downloads
File information
File name FULLTEXT01.pdfFile size 2366 kBChecksum SHA-512
b3137c00eff88002ce5bb07e35850d44ae78cff634bde9eb840c7576f62bd492a833050141c8c4a2c7db1c3caae4f3bcf3127afb354d36606e072c2029eb01aa
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sultan, Fahad
By organisation
Department of Integrative Medical Biology (IMB)
In the same journal
Brain Structure and Function
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 66 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 120 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf