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Heavy metals in fish and its association with autoimmunity in the development of juvenile idiopathic arthritis: a prospective birth cohort study
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Vastervik Hosp, Sweden; Skaraborg Hosp, Sweden.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
2019 (English)In: Pediatric Rheumatology, ISSN 1546-0096, E-ISSN 1546-0096, Vol. 17, article id 33Article in journal (Refereed) Published
Abstract [en]

BackgroundThe etiology of Juvenile Idiopathic Arthritis (JIA) is poorly understood. The purpose of this study was to examine the possible influence of early nutrition on later development of JIA.MethodsIn a population-based prospective birth cohort of 15,740 children we collected nutritional data, including fish consumption, and biological samples during pregnancy, at birth and at different ages. 16years after study inclusion we identified 42 children with JIA, of whom 11 were positive for Antinuclear Antibodies (ANA). Heavy metals were analysed in cord blood of all 42 JIA patients and 40 age and sex-matched controls. A multivariable logistic regression model, adjusted for relevant factors, was used as well as Mann-Whitney U-test.ResultsFish consumption more than once a week during pregnancy as well as during the childs first year of life was associated with an increased risk of JIA (aOR 4.5 (1.95-10.4); pamp;lt;0.001 and aOR 5.1 (2.1-12.4) pamp;lt;0.001) and of ANA-positivity (aOR 2.2 (1.4-3.6); p=0.002 and pamp;lt;0.001). Concentrations of Al, Cd, Hg and Li in cord blood were significantly higher in the JIA-group than in controls. The ANA-positive, all of whom had consumed fish amp;gt;once/week their first year, had significantly higher concentrations of Al (pamp;lt;0.001), Cd (p=0.003), and Li (pamp;lt;0.001) in cord blood than controls. Frequency of fish consumption correlated with concentrations of Cd (p=0.003), Li (p=0.015) and Hg (p=0.011).ConclusionsModerate exposure to heavy metals, associated with fish consumption, during pregnancy and early childhood may cause effects on the immune system of the offspring, resulting in ANA positivity and JIA.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 17, article id 33
Keywords [en]
Juvenile idiopathic arthritis (JIA); Arthritis; Epidemiology; Autoimmunity; Nutrition; Fish; Aluminium; Cadmium; Lithium; Heavy metals; Rheumatic disease
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-158930DOI: 10.1186/s12969-019-0344-3ISI: 000473638400001PubMedID: 31266504OAI: oai:DiVA.org:liu-158930DiVA, id: diva2:1338199
Note

Funding Agencies|Swedish Child Diabetes Foundation (Barndiabetesfonden); Juvenile Diabetes Research Foundation; Medical Research Council of Southeast Sweden (FORSS); Research Unit of Kalmar County Council; Research Fund at Skaraborgs Hospital; Skaraborg Research and Development Council; Swedish Rheumatism Association; Jerring Foundation; Escher Fund for Autism; ERC GeneWell grant

Available from: 2019-07-20 Created: 2019-07-20 Last updated: 2019-11-12

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Kindgren, ErikGuerrero Bosagna, CarlosLudvigsson, Johnny
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