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Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Örebro universitet.ORCID iD: 0000-0003-4088-9951
Lunds universitet.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Stockholms universitet.ORCID iD: 0000-0002-3395-2409
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn School of Medicine at Mount Sinai, NY, United States.ORCID iD: 0000-0003-0417-1686
2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, no 1, p. 1-7, article id 9179Article in journal (Refereed) Published
Abstract [en]

Preeclampsia is a major cause of maternal and fetal morbidity. Emerging research shows an association with environmental exposures. The present aim was to investigate associations between early pregnancy serum levels of perfluoroalkyl substances (PFAS) and preeclampsia. Within the Swedish SELMA study, eight PFAS were measured at median 10 gestational weeks and cases of preeclampsia were postnatally identified from registers. Associations between individual PFAS and preeclampsia were assessed, adjusting for parity, age, weight and smoking. Out of 1,773 women in the study group, 64 (3.6%), developed preeclampsia. A doubling of PFOS and PFNA exposure, corresponding to an inter-quartile increase, was associated with an increased risk for preeclampsia of about 38-53% respectively. Serum PFOS within the highest quartile was associated with an odds ratio of 2.68 (CI 95%: 1.17-6.12), equal to the increased risk associated with nulliparity, when compared to exposure in the first quartile. The same associations were identified, although with higher risk estimates, in analyses restricted to nulliparous women. For other PFAS, there were no associations. In conclusion and consistent with limited previous research only on PFOS, increasing serum levels of PFOS and PFNA during early pregnancy were associated with a clinically relevant risk of preeclampsia, adjusting for established confounders.

Place, publisher, year, edition, pages
Springer, 2019. Vol. 9, no 1, p. 1-7, article id 9179
National Category
Health Sciences
Research subject
Public Health Science
Identifiers
URN: urn:nbn:se:kau:diva-73525DOI: 10.1038/s41598-019-45483-7PubMedID: 31235847Scopus ID: 2-s2.0-85067898845OAI: oai:DiVA.org:kau-73525DiVA, id: diva2:1335831
Funder
Swedish Research Council FormasLandstinget i VärmlandAvailable from: 2019-07-08 Created: 2019-07-08 Last updated: 2019-07-15Bibliographically approved

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