Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Diffuse correlation spectroscopy for estimation of coagulation thickness: a phantom study
Linköping University, Department of Biomedical Engineering.
2019 (English)Independent thesis Advanced level (degree of Master (Two Years)), 300 HE creditsStudent thesis
Abstract [en]

The objective of this preliminary study was to determine the potential of diffuse correlation spectroscopy (DCS) for assessment of coagulation depth. Coagulation of tissue can occur due to a number of different reasons such as thermal or electrical burns or radiofrequency ablation. DCS is a non-invasive optical technique which can be used to determine the optical and dynamic properties of tissue by fitting a theoretical model of photon propagation in multiply scattering tissue to experimental data obtained from measurements. The DCS measurements were performed on two-layered phantom models that represent healthy tissue with high flow properties with a layer of coagulated tissue with low flow properties on top. Three different phantom models were prepared using gelatin-Intralipid gels, PDMS, and nylon as an upper layer, and an Intralipid solution was used for the bottom layer for all three phantoms. DCS measurements were performed on all three phantom models with varying thicknesses of the upper layers, and varying source-detector separations. The acquired data from the DCS measurement were analyzed in MATLAB in order to obtain the electric field temporal autocorrelation function. A theoretical model describing photon propagation in a two-layered medium was fitted to the obtained data in order to extract the desired parameters. The results showed that the thickness of the gelatin-Intralipid gels could be extracted within a 0.5 mm certainty and the thickness of the PDMS phantoms could also be extracted within approximately 0.7 mm. For the nylon phantoms, the results obtained were not good because the fitting was not successful and the thickness was not extracted appropriately. There is potential in DCS for assessment of burn wound depth but further research and development has to be done in the field in order to obtain more accurate and reliable results.

Place, publisher, year, edition, pages
2019. , p. 74
Keywords [en]
DCS, Diffuse correlation spectroscopy, Biomedical optics, coagulation, phantom study, coagulation depth, coagulation thickness, diffusion, model, two layer model
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-158622ISRN: LIU-IMT-TFK-A—19/563--SEOAI: oai:DiVA.org:liu-158622DiVA, id: diva2:1335255
Subject / course
Medical Technology
Presentation
2019-06-11, Nätverket, Campus US, Linköping, 13:15 (English)
Supervisors
Examiners
Available from: 2019-07-05 Created: 2019-07-04 Last updated: 2019-07-05Bibliographically approved

Open Access in DiVA

fulltext(3546 kB)27 downloads
File information
File name FULLTEXT01.pdfFile size 3546 kBChecksum SHA-512
e1dc05f2fa1fabfd2c84ad6083335dce2995a90fc41dee4ba3738df00b0d90c96c0614133d1da1a6c7159c20d190f5e1ad7e3f87e09c2c4337f5f501e4d05726
Type fulltextMimetype application/pdf

By organisation
Department of Biomedical Engineering
Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar
Total: 27 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 131 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf