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Genetical Genomics of Tonic Immobility in the Chicken
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. (AVIAN Behav Genom and Physiol Grp)
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
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2019 (English)In: Genes, ISSN 2073-4425, E-ISSN 2073-4425, Vol. 10, no 5, article id 341Article in journal (Refereed) Published
Abstract [en]

Identifying the molecular mechanisms of animal behaviour is an enduring goal for researchers. Gaining insight into these mechanisms enables us to gain a greater understanding of behaviour and their genetic control. In this paper, we perform Quantitative Trait Loci (QTL) mapping of tonic immobility behaviour in an advanced intercross line between wild and domestic chickens. Genes located within the QTL interval were further investigated using global expression QTL (eQTL) mapping from hypothalamus tissue, as well as causality analysis. This identified five candidate genes, with the genes PRDX4 and ACOT9 emerging as the best supported candidates. In addition, we also investigated the connection between tonic immobility, meat pH and struggling behaviour, as the two candidate genes PRDX4 and ACOT9 have previously been implicated in controlling muscle pH at slaughter. We did not find any phenotypic correlations between tonic immobility, struggling behaviour and muscle pH in a smaller additional cohort, despite these behaviours being repeatable within-test.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 10, no 5, article id 341
Keywords [en]
QTL; eQTL; tonic immobility; behaviour; domestication; muscle pH
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-158576DOI: 10.3390/genes10050341ISI: 000470964100020PubMedID: 31067744OAI: oai:DiVA.org:liu-158576DiVA, id: diva2:1334872
Note

Funding Agencies|Swedish Research Council (VR) [621-2011-4802]; Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) [221-2012-667]; European Research Council [GENEWELL 322206, FERALGEN 772874]

Available from: 2019-07-03 Created: 2019-07-03 Last updated: 2019-11-06

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