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Chronic widespread pain patients show disrupted cortical connectivity in default mode and salience networks, modulated by pain sensitivity
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-3587-3568
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Medical radiation physics. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-8661-2232
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2019 (English)In: Journal of Pain Research, ISSN 1178-7090, E-ISSN 1178-7090, Vol. 12, p. 1743-1755Article in journal (Refereed) Published
Abstract [en]

Purpose: The remodeling of functional neuronal connectivity in chronic widespread pain (CWP) patients remains largely unexplored. This study aimed to investigate functional connectivity in CWP patients in brain networks related to chronic pain for changes related to pain sensitivity, psychological strain, and experienced pain.

Patients and methods: Functional connectivity strength of the default mode network (DMN) and the salience network (SN) was assessed with functional magnetic resonance imaging. Between-group differences were investigated with an independent component analysis for altered connectivity within the whole DMN and SN. Then, changes in connectivity between nodes of the DMN and SN were investigated with the use of a seed-target analysis in relation to the covariates clinical pain intensity, pressure pain sensitivity, psychological strain, and as an effect of experienced experimental cuff-pressure pain.

Results: CWP patients showed decreased connectivity in the inferior posterior cingulate cortex (PCC) in the DMN and increased connectivity in the left anterior insula/superior temporal gyrus in the SN when compared to controls. Moreover, higher pain sensitivity in CWP when compared to controls was related to increased connectivity within the SN (between left and right insula) and between SN and DMN (between right insula and left lateral parietal cortex).

Conclusion: This study shows that connectivity within the DMN was decreased and connectivity within the SN was increased for CWP. Furthermore, we present a novel finding of interaction of pain sensitivity with SN and DMN-SN functional connectivity in CWP.

Place, publisher, year, edition, pages
Macclesfield, United Kingdom: Dove Medical Press Ltd.(Dovepress) , 2019. Vol. 12, p. 1743-1755
Keywords [en]
functional connectivity; functional magnetic resonance imaging; fMRI; default node network; DMN; salience network
National Category
Physiotherapy
Identifiers
URN: urn:nbn:se:liu:diva-158386DOI: 10.2147/JPR.S189443ISI: 000469348300001PubMedID: 31213886Scopus ID: 2-s2.0-85069468990OAI: oai:DiVA.org:liu-158386DiVA, id: diva2:1333601
Note

Funding Agencies|Forskningsradet i Sydostra Sverige (FORSS [Medical Research Council of Southeast Sweden]); Danish National Research Foundation [DNRF121]; Swedish Research Council

Available from: 2019-07-01 Created: 2019-07-01 Last updated: 2019-11-05Bibliographically approved

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Veenstra, HeleneLundberg, PeterAlföldi, PéterSödermark, MartinEngström, MariaGerdle, Björn
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