Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Optoelectronic control of single cells using organic photocapacitors
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. (Wallenberg Centre for Molecular Medicine)
Med Univ Graz, Austria.
Show others and affiliations
2019 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 5, no 4, article id eaav5265Article in journal (Refereed) Published
Abstract [en]

Optical control of the electrophysiology of single cells can be a powerful tool for biomedical research and technology. Here, we report organic electrolytic photocapacitors (OEPCs), devices that function as extracellular capacitive electrodes for stimulating cells. OEPCs consist of transparent conductor layers covered with a donor-acceptor bilayer of organic photoconductors. This device produces an open-circuit voltage in a physiological solution of 330 mV upon illumination using light in a tissue transparency window of 630 to 660 nm. We have performed electrophysiological recordings on Xenopus laevis oocytes, finding rapid (time constants, 50 mu s to 5 ms) photoinduced transient changes in the range of 20 to 110 mV. We measure photoinduced opening of potassium channels, conclusively proving that the OEPC effectively depolarizes the cell membrane. Our results demonstrate that the OEPC can be a versatile nongenetic technique for optical manipulation of electrophysiology and currently represents one of the simplest and most stable and efficient optical stimulation solutions.

Place, publisher, year, edition, pages
Washington, DC, United States: American Association for the Advancement of Science (A A A S) , 2019. Vol. 5, no 4, article id eaav5265
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-158380DOI: 10.1126/sciadv.aav5265ISI: 000466398400064PubMedID: 30972364Scopus ID: 2-s2.0-85064722157OAI: oai:DiVA.org:liu-158380DiVA, id: diva2:1333596
Note

Funding Agencies|Knut and Alice Wallenberg Foundation; Swedish Foundation for Strategic Research (SSF); Swedish Research Council (Vetenskapsradet) [2018-04505]

Available from: 2019-07-01 Created: 2019-07-01 Last updated: 2019-11-05Bibliographically approved

Open Access in DiVA

fulltext(3268 kB)8 downloads
File information
File name FULLTEXT01.pdfFile size 3268 kBChecksum SHA-512
e7bba435d270a273eaa5071e845552aa0484da814e51703dce971a691f1844806b561511bc2086de4dc61ba0257ff990236fed84536d6037f1f3abfcaccc6f7d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Jakesova, MarieSilverå Ejneby, MalinDerek, VedranGryszel, MaciejBrask, JohanSimon, DanielBerggren, MagnusElinder, FredrikGlowacki, Eric
By organisation
Laboratory of Organic ElectronicsFaculty of Science & EngineeringDivison of NeurobiologyFaculty of Medicine and Health Sciences
In the same journal
Science Advances
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 8 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 460 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf