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Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study
VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium.
VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Nutricia Res, Nutricia Adv Med Nutr, Utrecht, Netherlands.
VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium.
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2019 (English)In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319, Vol. 31, no 6, p. 845-854Article in journal (Refereed) Published
Abstract [en]

Background A chronic low-grade infammatory profle (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for efects of nutritional supplementation on CLIP is limited. Aim To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein afected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis. Methods Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4–9) and a body mass index of 20–30 kg/m2 were randomly allocated to two daily servings of active (n=137, including 20 g of whey protein, 3 g of leucine and 800 IU VitD) or isocaloric control product (n=151) for a double-blind period of 13 weeks. At baseline and after 13 weeks, circulating interleukin (IL)-8, IL-1 receptor antagonist (RA), soluble tumor-necrosis-factor receptor (sTNFR)1, IL-6, high-sensitivity C-reactive protein, pre-albumin and 25-hydroxyvitamin(OH) D were measured. Data-analysis included repeated measures analysis of covariance (corrected for dietary VitD intake) and linear regression. Results IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p=0.006 and p<0.001, respectively). For IL-6 a signifcant time × treatment interaction (p=0.046) was observed, with no signifcant change over time in the active group (p=0.155) compared to control (signifcant increase p=0.012). IL-8 showed an overall signifcant decrease (p=0.03). The change in pre-albumin was a signifcant predictor for changes in IL-6 after 13 weeks. Conclusions We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.

Place, publisher, year, edition, pages
SPRINGER , 2019. Vol. 31, no 6, p. 845-854
Keywords [en]
Vitamin D, Leucine, Whey proteins, Dietary supplements, Cytokines, Aged
National Category
Nutrition and Dietetics Geriatrics Gerontology, specialising in Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-387920DOI: 10.1007/s40520-019-01208-4ISI: 000470272200013PubMedID: 31049877OAI: oai:DiVA.org:uu-387920DiVA, id: diva2:1332072
Available from: 2019-06-27 Created: 2019-06-27 Last updated: 2019-06-27Bibliographically approved

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