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Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA - update 2018
Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA.ORCID iD: 0000-0001-5692-2723
Johns Hopkins Univ, James Buchanan Brady Urol Inst, Baltimore, MD USA.
Univ Wisconsin, Dept Urol, Madison, WI USA.
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2019 (English)In: Nature reviews. Urology, ISSN 1759-4812, E-ISSN 1759-4820, Vol. 16, no 6, p. 377-386Article, review/survey (Refereed) Published
Abstract [en]

Blue light cystoscopy (BLC) with hexaminolevulinate (HAL) during transurethral resection of bladder cancer improves detection of non-muscle-invasive bladder cancer (NMIBC) and reduces recurrence rates. Flexible BLC was approved by the FDA in 2018 for use in the surveillance setting and was demonstrated to improve detection. Results of a phase III prospective multicentre study of blue light flexible cystoscopy (BLFC) in surveillance of intermediate-risk and high-risk NMIBC showed that 20.6% of malignancies were identified only by BLFC. Improved detection rates in the surveillance setting are anticipated to lead to improved clinical outcomes by reducing future recurrences and earlier identification of tumours that are unresponsive to therapy. Thus, BLFC has a role in surveillance cystoscopy, and determining which patients will benefit from BLFC and optimal and cost-effective ways of incorporating this technology into surveillance cystoscopy must be developed.

Place, publisher, year, edition, pages
2019. Vol. 16, no 6, p. 377-386
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Urology and Nephrology
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URN: urn:nbn:se:uu:diva-387986DOI: 10.1038/s41585-019-0184-4ISI: 000470118100010PubMedID: 31019310OAI: oai:DiVA.org:uu-387986DiVA, id: diva2:1332024
Available from: 2019-06-27 Created: 2019-06-27 Last updated: 2019-06-27Bibliographically approved

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